Cell Signaling of Host Defense

国立环境卫生科学研究所呼吸生物学实验室校内研究部宿主防御小组，由Michael B领导。Fessler，MD现在进入了自成立以来在NIEHS的第十一个年头。 自上次年度报告以来的出版物包括： 1. 一篇关于靶向肝脏X受体的药物治疗人类炎症性疾病的潜力的邀请综述文章（Pubmed ID 28720427） 2. 美国胸科学会关于肥胖对肺部疾病影响的协作研讨会报告（Pubmed 28570148） 3. 关于TAK1激酶在巨噬细胞发育中的作用的合作论文（Pubmed ID 28182011） 4. 关于应激反应基因TNFAIP8在人类癌症中的作用的资深作者出版物（Pubmed ID 27834950） 5. 一篇关于炎性疾病中肺表面活性物质脂质的综述文章（Pubmed ID 27286794） 6. 关于臭氧对疾病中肝脏X受体影响的合作论文（Pubmed ID 27703007） 7. 关于蛋白质组学研究的新型化学交联剂的合作论文（Pubmed ID 27649375） 8. 关于细胞胆固醇在免疫中的作用的特邀评论文章（Pubmed ID 27692616） 自我们上次报告以来的其他成就包括授予Fessler博士作为《美国呼吸细胞和分子生物学杂志》的顶级评审员的奖项，Fessler博士在瑞士卢塞恩举行的跨大西洋气道会议上的国际演讲，以及Fessler博士在马里兰州贝塞斯达举行的NIH炎症性疾病兴趣小组研讨会系列上的演讲。

The Host Defense Group of the Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, headed by Michael B. Fessler, MD now enters its eleventh year at the NIEHS since inception. Publications since the last annual report include: 1. an invited review article on the potential for drugs targeting Liver X Receptor for treatment of inflammatory diseases in humans (Pubmed ID 28720427) 2. a collaborative workshop report through the American Thoracic Society on the effects of obesity on lung disease (Pubmed 28570148) 3. a collaborative paper on the role of TAK1 kinase in macrophage development (Pubmed ID 28182011) 4. a senior author publication on the role the stress response gene TNFAIP8 in human cancer (Pubmed ID 27834950) 5. a review article on pulmonary surfactant lipids in inflammatory disease (Pubmed ID 27286794) 6. a collaborative paper on the effect of ozone on Liver X Receptor in disease (Pubmed ID 27703007) 7. a collaborative paper on a novel chemical crosslinker for proteomics studies (Pubmed ID 27649375) 8. an invited review article on the role of cellular cholesterol in immunity (Pubmed ID 27692616) Additional accomplishments since our last report include an award to Dr. Fessler for being a Top Reviewer of the American Journal of Respiratory Cell and Molecular Biology, an invited international presentation by Dr. Fessler at the Transatlantic Airway Conference in Lucerne, Switzerland, and an invited presentation by Dr. Fessler at the NIH Inflammatory Disease Interest Group Seminar Series in Bethesda, MD.