Graduated sensory salience as an intervention for intrusive negative thinking

 描述（由申请人提供）：侵入性消极认知是许多精神疾病的关键转诊断特征，难以治疗，并且在常规和神经行为干预中预测不良结局。在这里，我们评估在何种程度上，一种新的干预利用保留的神经回路参加进化显着的躯体感觉刺激，可用于训练注意力机制，以覆盖否则pre-potent负面认知。R21期将涉及干预细化和机制的机械评价;将在干预前/后评估N=35名具有高水平侵入性负面认知和烦躁不安的个体。R33阶段将涉及与对照条件的机械比较和心理测量评估; N=60名具有高水平侵入性负面认知和相关烦躁不安的个体将接受主动干预，包括直接关注身体感觉的分级降低程度（N=40）或非分级对照条件（N=40）。在干预前后，将通过神经成像评估这些个体对非情绪和情绪刺激的注意力集中机制，沿着20名健康对照参与者，他们将接受两次评估。成功将为精神病理学的传统治疗抗性维度提供一种新的干预途径。

 DESCRIPTION (provided by applicant): Intrusive negative cognitions are key transdiagnostic features of many psychiatric disorders, are difficult to treat, and predict poor outcomes in conventional and neurobehavioral interventions. Here, we evaluate the extent to which a novel intervention capitalizing on a preserved neurocircuitry for attending to evolutionarily salient somatosensory stimuli can be used to train attentional mechanisms to override otherwise pre-potent negative cognitions. The R21 period will involve intervention refinement and mechanistic evaluation of mechanism; N=35 individuals with high levels of intrusive negative cognitions and dysphoria will be assessed pre/post intervention. The R33 phase will involve mechanistic comparison to control conditions and psychometric evaluation; N=60 individuals with high levels of intrusive negative cognitions and associated dysphoria will undergo either an active intervention involving directed attention to graduated decreasing degrees of physical sensation (N=40) or a non-graduated control condition (N=40). Mechanisms of attentional focus on non-emotional and emotional stimuli will be assessed via neuroimaging in these individuals before and after the intervention along with 20 healthy control participants who will be assessed a twice. Success will suggest a new intervention pathway for a traditionally treatment-resistant dimension of psychopathology.