Acupuncture for Chemothrapy-induced Peripheral Neuropathy Treatment (ACT)Trial

项目摘要 化疗最有害的副作用之一是化疗引起的外周血淋巴细胞减少。 神经病变（CIPN），许多化疗药物的常见、疼痛和致残副作用 没有有效的治疗方法。我们的IIB期三臂试验表明， 针灸治疗与减少CIPN疼痛和改善触觉阈值有关 与安慰剂和常规护理对照相比。我们的目标是提高癌症患者的功能， 通过确定有效的治疗方法来减轻化疗相关的毒性，从而提高生活质量。的 该项目的目标是确定针灸治疗CIPN疼痛的疗效 以及改善癌症幸存者的感觉神经恢复 患有中度至重度CIPN疼痛。我们将进行第三阶段，250名病人， 随机，安慰剂（假针灸）对照试验，以：1）确定疗效的一个 八周电针治疗对中重度癌症幸存者CIPN症状的影响 CIPN疼痛; 2）评估EA相对于SA对小感觉纤维功能的影响;以及3）评估 基线QST结果是否预测EA的反应。

Project Summary One of the most harmful side effects of chemotherapy is chemotherapy-induced peripheral neuropathy (CIPN), a common, painful, and disabling side effect of many chemotherapy agents for which there is no effective treatment. Our pilot phase IIB three-arm trial showed that acupuncture treatment is associated with reduced CIPN pain and improved tactile threshold compared to placebo and usual care control. We aim to increase cancer patients' function and quality of life by identifying effective treatments to alleviate chemotherapy-related toxicities. The goal of the proposed project is to determine the efficacy of acupuncture in treating CIPN pain and improving function, as well as to improve sensory nerve recovery in cancer survivors suffering from moderate to severe CIPN pain. We will conduct a phase III, 250-patient, randomized, placebo (sham acupuncture)-controlled trial to: 1) determine the efficacy of an eight-week EA treatment on CIPN symptoms among cancer survivors with moderate to severe CIPN pain; 2) evaluate the effect of EA vs. SA on small sensory fiber function; and 3) evaluate whether baseline QST outcomes predict response to EA.