Hot Flashes and Neurovascular Function in Women

项目总结/摘要 与更年期相关的血管炎症状（潮热）包括快速和剧烈的出汗， 外周血管扩张，以及夸大的内热感。超过70%的女性经历过热 在更年期的某个时候会闪烁，这会严重影响日常生活。此外，Hot Flash 频率与高血压、心血管疾病（CVD）、睡眠和情绪的风险增加有关 疾病-即使在控制传统的心血管疾病风险因素（肥胖，高血压， 脂质等）。因此，本申请的总体目标是确定心脏中的自主神经血管功能。 中年妇女有和没有血管炎症状（潮热）。就本申请而言，我们将 将神经血管功能定义为一个概念，包括交感神经流出，血液的反应， 血管对交感神经释放的神经递质和血管的固有特性的影响 内皮和平滑肌。因此，它与组织血流的调节有关。在这一背景下， 神经血管功能对女性的健康和衰老至关重要。目标1将比较微血管 客观评估低频率和高频率潮热女性的功能。目标2将决定 客观评估低频率和高频率潮热妇女的自主神经功能和反应性。 最后，目标3将描述客观评估为低和高的女性的脑血管功能 频繁潮热重要的是，这项工作将提供第一个全面和机械的评价， 植物神经和神经血管功能的中年妇女，包括那些正在经历更年期。 了解女性的神经血管生理学与潮热的关系将有助于了解高血压和 心血管疾病（CVD）的治疗和预防选择，因为潮热的存在是CVD的风险 这一因素超出了传统的心血管疾病风险因素，因此，可能是一个重要的决定因素，为妇女的 健康因此，申请人的长期目标是开发干预措施，以减少 心血管疾病的妇女与潮热。拟议的研究将建立在申请人以前的 培训和指导团队，关于运行临床试验的正式课程工作，以及技术培训计划将 提供获得新领域的额外知识和学习新实验技术的机会， 接近。最后，这项工作将产生一个调查利基，将补充申请人的 知识和技能，这将有助于她独立的职业生涯的启动。

PROJECT SUMMARY/ABSTRACT Vasomotor symptoms (hot flashes) associated with menopause consist of rapid and intense sweating, peripheral vasodilation, and an exaggerated feeling of internal heat. Over 70% of women experience hot flashes at some point during menopause, which significantly impacts day to day life. Furthermore, hot flash frequency is related to increased risk of hypertension, cardiovascular disease (CVD), sleep, and mood disorders--even when controlling for traditional cardiovascular disease risk factors (obesity, hypertension, lipids, etc.). As such, the overall goal of this application is to determine autonomic neurovascular function in midlife women with and without vasomotor symptoms (hot flashes). For the purposes of this application we will define neurovascular function as a concept that encompasses sympathetic outflow, the responses of blood vessels to neurotransmitters released by the sympathetic nerves and the intrinsic properties of the vascular endothelium and smooth muscle. It is thus related to the regulation of tissue blood flow. In this context, neurovascular function is critically important to women’s health and aging. Aim 1 will compare microvascular function in women with objectively assessed low and high frequency hot flashes. Aim 2 will determine autonomic function and reactivity in women with objectively assessed low and high frequency hot flashes. Finally, Aim 3 will characterize cerebrovascular function in women with objectively assessed low and high frequency hot flashes. Importantly, this work will provide the first comprehensive and mechanistic evaluation of autonomic and neurovascular function in midlife women including those undergoing menopause. Understanding how the neurovascular physiology of women relates to hot flashes will inform hypertension and cardiovascular disease (CVD) treatment and prevention options, as the presence of hot flashes are a CVD risk factor beyond traditional CVD risk factors and as such, is likely to be an important determinant for a woman’s health. Thus, the Applicant’s long-term goal is to develop interventions to reduce the incidence of cardiovascular disease in women with hot flashes. The proposed studies will build on the Applicant’s previous training and the mentorship team, formal course work on running clinical trials, and technical training plan will provide opportunities to gain additional knowledge in a new area and learn new experimental techniques and approaches. Finally, this work will generate an investigative niche that will complement the Applicant’s intellectual and technical skills that will facilitate the launch of her independent career.