Measuring the Impact of Racism-Induced Medical Mistrust on Placebo Analgesia.

项目总结 这个为期五年的K23导师职业发展奖的总体目标是提供批判性研究和 职业发展机会，这将有助于应聘者成为领导者的长期职业目标 疼痛治疗反应的神经心理社会机制方面的专家，特别是针对服务不足的种族/民族的 组。拟议的K23活动将基于候选人在身心疼痛干预方面的背景， 情感疼痛机制，和静息状态功能磁共振成像方法，通过完成研讨会，在线 以下领域的课程作业、导师会议、研讨会和会议：[1]疼痛差异，[2] 社区参与研究，[3]安慰剂止痛，[4]基于任务的功能磁共振成像。候选人已集结 优秀的合作导师团队，在疼痛差异方面具有专业知识(主要导师克劳迪娅·坎贝尔博士)， 社区参与研究(共同导师米歇尔·埃文斯博士)，安慰剂止痛药(共同导师卢安娜·科洛卡博士)， 以及基于任务的功能磁共振成像(共同导师劳伦·阿特拉斯博士)，她将监督她的进展。通过K23学习的技能 职业发展计划将实际应用于完成一项研究项目，审查 种族主义引起的医疗不信任(即由于以下影响而对医疗系统的不信任)之间的联系 结构性和人际种族主义)、安慰剂止痛(即神经心理学产生的疼痛缓解 对背景线索的反应)，以及生活在美国社会文化中的黑人成年人的伴随脑活动 周围的环境。安慰剂止痛将使用适用于功能磁共振成像环境的成熟方案进行诱导。此外， 该项目将是第一个收集有关安慰剂可接受性(即，可接受安慰剂作为疼痛)的信息的项目 治疗)，特别是在黑人成年人中，并将询问有助于促进 安慰剂止痛药。该项目的结果将提供支持大规模赠款的关键试点数据 意见书旨在优化居住在美国的黑人成年人的安慰剂止痛干预措施。此外， 完成职业发展计划将为应聘者提供必要的技能、资源和 社区伙伴关系，以建立和维护一个独立的研究计划，使用最先进的 改善服务不足的种族/民族的疼痛治疗结果的方法。

PROJECT SUMMARY The overall goal of this five-year K23 Mentored Career Development Award is to provide critical research and career development opportunities that will facilitate the candidate’s long-term career goal of being a leading expert in neuropsychosocial mechanisms of pain treatment responses, particularly for underserved racial/ethnic groups. The proposed K23 activities will build on the candidate’s background in mind-body pain interventions, affective pain mechanisms, and resting-state fMRI methods through the completion of workshops, online coursework, mentor meetings, seminars, and conferences in the following areas: [1] pain disparities, [2] community-engaged research, [3] placebo analgesia, and [4] task-based fMRI. The candidate has assembled an outstanding team of co-mentors with expertise in pain disparities (primary mentor Dr. Claudia Campbell), community-engaged research (co-mentor Dr. Michele Evans), placebo analgesia (co-mentor Dr. Luana Colloca), and task-based fMRI (co-mentor Dr. Lauren Atlas) who will oversee her progress. Skills learned through the K23 career development plan will be practically applied in the completion of a research project examining the association between racism-induced medical mistrust (i.e., mistrust of healthcare systems due to the effects of structural and interpersonal racism), placebo analgesia (i.e., pain relief resultant from neuropsychological responses to contextual cues), and concomitant brain activity among Black adults living in the US sociocultural milieu. Placebo analgesia will be induced using a well-established protocol for the fMRI environment. Further, this project will be the first to collect information about placebo acceptability (i.e., admissibility to placebo as pain treatment) specifically among Black adults and will query for culturally responsive factors that can help boost placebo analgesia. Results from this project will provide critical pilot data that will support a large-scale grant submission aiming to optimize placebo analgesia interventions for US-residing Black adults. Further, the completion of the career development plan will give the candidate the necessary skills, resources, and community partnerships to build and maintain an independent program of research using state-of-the-art methods to improve pain treatment outcomes for underserved racial/ethnic groups.