Defining Pathways in COPD Patient Oriented Research

摘要 韩博士是一位内科科学家，专注于慢性阻塞性肺疾病(COPD)患者导向的研究 研究(POR)。此续订申请将继续确保她有受保护的时间专注于指导 和职业发展。韩博士的职业目标是继续开发COPD POR计划，以更好地 了解这种疾病隐含的疾病异质性，从而最终可以 发展起来的。获得这一奖项的保护时间将允许她参加额外的课程学习，以获得新的 分析和指导技能。根据这一奖项，她的指导目标将是保留受保护的时间 继续培训住院医师、研究员、研究生和初级教员，特别是初级教员 调查人员，特别是妇女和少数群体，目前在COPD POR中代表性不足。韩博士 将继续为每个学员量身定制指导计划，包括一对一的指导会议， 与统计学家的合作以及在分析方法和责任人方面的正规教育机会 进行研究。密歇根大学(UM)可用的资源，包括UM肺 分部多学科培训补助金和密歇根临床与健康研究所/临床与健康研究所 翻译科学奖为POR培训提供了理想的基础设施。韩博士的科学目标是 该提案将利用几个新资助的项目，为初级调查人员提供培训机会。 新出现的数据表明，慢性阻塞性肺疾病在生命中开始的时间比之前认识到的要早得多。CT分析 在密歇根大学开发的技术(参数反应图，PRM)可以识别小气道疾病， 被认为是肺气肿的前驱病变。韩博士是SPIROMICS队列的扩展之一 (HL144718)正在招募30-55岁的现任和前任吸烟者，这些吸烟者要么有慢性阻塞性肺病的风险，要么有轻度到 中度确诊的慢性阻塞性肺疾病。在目标1中，我们将使用早期COPD的这些数据来确定PRM是否 明确的小气道疾病可以在这样的个体中识别出来，以预测疾病的进展。第二 本提案的具体目的将使用韩博士联系Pi的R01(HL150023)生成的数据。在AIM 2、将在COPD基因队列中进行纵向PRM分析，以确定10年纵向PRM 高危吸烟者中小气道疾病和肺气肿的演变轨迹 年龄40-80岁，有无慢性阻塞性肺疾病。这些分析共同提供了一种新的成像生物标记物的数据 跨越寿命和疾病严重程度范围，并为青少年提供丰富的研究机会 调查人员。韩博士正处于职业生涯的理想阶段，可以利用K24奖项。她深深地 致力于她在COPD POR的调查生涯。此应用程序还符合两个NHLBI任务：(1) 促进预防和治疗肺部疾病的研究、培训和教育；及 增加我国肺病研究队伍的多样性。

ABSTRACT Dr. Han is a physician scientist with a focus in chronic obstructive pulmonary disease (COPD) patient-oriented research (POR). This renewal application will continue to secure her with protected time to focus on mentoring and career development. Dr. Han’s career goal is to continue developing a COPD POR program to better understand disease heterogeneity implicit to this disease so that ultimately disease modifying therapies can be developed. Protected time from this award would allow her to take additional coursework to acquire new analytic and mentoring skills. Her mentoring objectives under this award will be to retain protected time to continue to train residents, fellows, graduate students and junior faculty, focusing in particular on junior investigators, in particular women and minorities, who are currently underrepresented in COPD POR. Dr. Han will continue to tailor mentoring plans to each trainee, consisting of one-on-one mentoring sessions, collaboration with statisticians and formal educational opportunities in analytic methods and the responsible conduct of research. The resources available at the University of Michigan (UM) including the UM Pulmonary Division Multidisciplinary Training Grant and the Michigan Institute for Clinical & Health Research/Clinical & Translational Science Award provide an ideal infrastructure for POR training. Dr. Han’s scientific aims for this proposal will leverage several newly funded projects to provide training opportunities for junior investigators. Emerging data suggest that COPD begins much earlier in life than previously appreciated. CT analytic techniques (Parametric Response Mapping, PRM) developed at UM can identify small airway disease, believed to be the precursor lesion to emphysema. Dr. Han is Co-PI of an extension to the SPIROMICS cohort (HL144718) that is recruiting 30-55 year-old current and former smokers either at risk for COPD or with mild to moderate established COPD. In Aim 1, we will use these data in early COPD to determine whether PRM defined small airways disease can be identified in such individuals to predict disease progression. The second specific aim of this proposal will use data generated by R01 (HL150023) for which Dr. Han is contact PI. In Aim 2, longitudinal PRM analyses in the COPDGene cohort will be performed to determine 10-year longitudinal trajectories for evolution of small airways disease and emphysema among at risk current and former smokers aged 40-80, with and without COPD. Together these analyses provide data on a novel imaging biomarker across the lifespan and disease severity spectrum and provide a wealth of research opportunities for junior investigators. Dr. Han is at an ideal stage of her career to take advantage of a K24 award. She is deeply committed to her investigative career in COPD POR. This application also aligns with two NHLBI missions: (1) to promote research, training, and education for the prevention and treatment of lung disease; and (2) increasing the diversity of our national lung disease research workforce.