Emerge: Emerging Diseases Epidemiology Research Training

项目主任/首席调查员(最后、第一、中间)：Lescano，Andres G. 过去的五年是南美洲动荡的时期，寨卡病毒及其 先天性综合征，巴西黄热病爆发，有可能耗尽区域疫苗 储备、导致大规模移民和麻疹爆发的委内瑞拉危机以及史无前例的 疟疾病例激增，削弱了疟疾控制方面取得的进展。事实上，秘鲁受到了 这些挑战，并遭受了有记录以来最大规模的登革热疫情，近7万例病例和89人死亡 在2017年海岸厄尔尼诺事件突然发生后。因此，要加强早期发现和有效应对 针对这些疫情威胁，我们将向卫生部提供高级硕士和博士培训机会 卫生人员。这将在亚马逊盆地创建一个流行病学硕士项目，并加强我们的 秘鲁北部海岸的卫星研究单位，并确保我们的新卫星的长期可持续性 流行病学博士学位。这些战略将导致更多训练有素的流行病学家，以及 出现在最需要它们的关键、高风险区域。我们的目标将是巩固和 通过复制成功的模式，在秘鲁获得自我可持续和具有成本效益的流行病学博士学位 我们的硕士项目，并建立一个持续不断的新出现的疾病流行病学家的管道来应对 疫情和防控工作。未来五年的预期成果是：1)20名博士 秘鲁方案的毕业生和另外12人正在接受精简课程的培训，以提高 毕业和研究成果，2)30名新的、分散的流行病学硕士项目的毕业生 在伊基托斯和我们利马硕士的另外90名毕业生中，约15%的人在新兴市场进行研究 疾病，约20%来自公共部门，3)秘鲁疾控中心1名博士和5名硕士毕业生 与美国疾病控制与预防中心联合培训，4)六名精选的秘鲁博士接受世界级项目培训 在国外，四人重新进入秘鲁从事富有成效的研究事业，5)一大批年轻专业人员 通过现场实习(30人)和短期课程(150人)培训和参与新出现的疾病研究。 在世界级机构如卡耶塔诺、圣马科斯、米纳斯吉拉斯和 约翰霍普金斯大学将与秘鲁和美国疾控中心合作，由30个当地和 在秘鲁工作的外国组织。该计划的合作伙伴提供了一个独特的、丰富的和培育的 从美国国立卫生研究院和其他来源获得广泛的多年赠款资金的研究环境，以促进 创新和解决公共卫生和科学意义的假说，特别是对于树状病毒病， 抗菌素耐药性、呼吸道感染和人畜共患病。我们的过往记录证明 在秘鲁获得流行病学硕士和博士学位后提出的目标构想 200名硕士研究生，并在美国和英国为16名秘鲁科学家提供博士培训 大学。我们近15%的硕士学生已经进入博士培训，我们的第一批 仅毕业后就发表了200篇论文，与之前的课程相比增长了四倍。 我们在国外的博士生中有一半以上已经毕业并开始了富有成效的科学职业生涯，而且 总体而言，他们平均每篇发表了11篇手稿。目前和未来的受训人员可能是 由于增加了研究机会、改进了课程作业和增加了指导，工作效率甚至更高。 OMB编号0925-0001/0002(01/18修订版批准至2020年3月31日)页面续格式页面

Program Director/Principal Investigator (Last, First, Middle): LESCANO, Andres G. The last five years have been a volatile period in South America with the massive emergence of Zika and its congenital syndrome, the Brazil yellow fever outbreak that threatened to exhaust the regional vaccine stockpile, the Venezuelan crisis that led to significant migration and measles outbreaks, and an unprecedented surge in malaria cases that crippled the progress achieved in malaria control. Indeed, Peru was affected by these challenges and suffered its largest dengue outbreak on record with nearly 70,000 cases and 89 deaths after the sudden 2017 Coastal El Niño event. Therefore, to strengthen early detection and effective responses to these epidemic threats, we will provide advanced Master’s and doctoral training opportunities to Ministry of Health personnel. This will create an Epidemiology Master’s program in the Amazon Basin and strengthen our satellite research unit on the northern coast of Peru and secure the long-term sustainability of our new epidemiology doctorate. These strategies will result in better-trained epidemiologists in larger numbers, and present in the critical, high-risk areas where they are needed the most. Our objective will be to consolidate and secure a self-sustainable and cost-effective epidemiology doctorate in Peru by replicating the successful model of our Master’s program and creating a continuous pipeline of emerging diseases epidemiologists to respond to outbreaks and prevention and control efforts. The expected outcomes for the next five years are: 1) 20 PhDs graduates from the Peru program and 12 more under training with a streamlined curricula to improve graduation and research outcomes, 2) 30 graduates from a new, decentralized Epidemiology Master’s program in Iquitos and 90 additional graduates from our Lima Master’s, ~15% conducting research in emerging diseases and ~20% from the public sector, 3) One doctoral and five Master’s graduates of the Peruvian CDC trained jointly with the US CDC, 4) Six highly-selected Peruvian doctorates trained in world-class programs abroad, four reinserted in Peru in productive research careers, 5) A large pipeline of young professionals trained and engaged in emerging diseases research via on-site internships (30) and short courses (150). Experienced research leaders in world-class institutions such as Cayetano, San Marcos, Minas Gerais and Johns Hopkins universities will partner with Peru and US CDC supported by a broad network of 30 local and foreign organizations working in Peru. The partners of this program provide a unique, rich and nurturing research environment with extensive multi-year grant funding from the NIH and other sources that promotes innovation and addresses hypothesis of public health and scientific significance, particularly for arbovirosis, antimicrobial resistance, respiratory infections and zoonotic diseases. Our track record demonstrates proof of concept for the proposed goals after creating an Epidemiology Master’s and Doctorate in Peru, graduating over 200 Master’s students and sponsoring doctoral training for 16 Peruvian scientists at prestigious US and UK universities. Almost 15% of our Master’s students have already moved into PhD training, and our first cohort alone has published >200 papers after graduating, a four-fold increase year compared to prior coursework. More than half of our doctoral trainees abroad have graduated and started productive scientific careers, and overall, they have published an average of 11 manuscripts each. Current and future trainees are likely to be even more productive due to enhanced research opportunities, improved coursework and added mentoring. OMB No. 0925-0001/0002 (Rev. 01/18 Approved Through 03/31/2020) Page Continuation Format Page