Core A: Administrative Core

摘要-核心A：行政核心 行政核心（AC）的主要职能是：a）最大限度地扩大地方，全州和全国的影响 密歇根州ADRC制定和实施的举措; B）加强三者之间的合作 组成联盟的伙伴大学（密歇根大学、韦恩州立大学和密歇根大学 州立大学）和NACC，NCRAD和外部调查人员; c）为财政提供健全的监督 d）确保所资助的研究和活动严谨、公正和透明 在中心。咨询委员会的稳定领导确保了各种研究、培训和外联举措 由核心管理将保持协同作用和连接到密歇根州ADRC的中心主题，这是 识别、理解和调节导致脑功能障碍的无数非β-淀粉样蛋白因子， AD和相关痴呆中的神经变性。AC将确保为所有人提供广泛支持的环境 调查员，但特别是初级调查员，目标是培养一个多样化的小组， 一代领导人。为了发挥ADRC的最大作用，AC将与其他中心密切合作， 参与年龄相关研究的联盟计划，包括六个由NIA资助的 这些中心共同组成了UMAging倡议。在六个目标中，AC将：1）利用专家痴呆症 资源和技能集中在每个核心; 2）保持核心之间的相互作用; 3）维持现有的 （4）维持现有的国家伙伴关系，并建立更多的国家伙伴关系; 促进努力解决民主与复兴运动中的种族和族裔不平等问题;以及 通过各种研究和培训机会。在其作为NIH指定的ADRC的第一个周期中，密歇根州 ADRC实现了其里程碑，部分原因是积极主动的AC帮助建立了全州范围的关键伙伴关系。 受益于我们校园内许多互补的NIA资助项目的密切联系， 所有三所大学的杰出额外资源，以及持续的慈善成功，密歇根大学 ADRC处于有利地位，可以进一步丰富创新的痴呆症研究，推广和培训工作， 区域和国家。

ABSTRACT – CORE A: ADMINISTRATIVE CORE The key functions of the Administrative Core (AC) are to: a) maximize the local, statewide and national impact of initiatives developed and implemented by the Michigan ADRC; b) enhance collaborations across the three partner universities comprising the consortium (University of Michigan, Wayne State University and Michigan State University) and with the NACC, NCRAD and outside investigators; c) provide sound oversight for fiscal and personnel matters; and d) ensure rigor, integrity and transparency in the research and activities supported by the center. The AC’s stable leadership ensures that the various research, training and outreach initiatives managed by the Cores will maintain synergy and connection to the Michigan ADRC’s central theme, which is to identify, understand and modulate the myriad non-β-amyloid factors that contribute to brain dysfunction and neurodegeneration in AD and related dementias. The AC will ensure a broadly supportive environment for all investigators, but particularly for junior investigators, with the goal of nurturing a diverse group of next- generation leaders. To have maximal effect as an ADRC, the AC will work closely with other centers and programs across the consortium that are engaged in age-related research, including the six NIA-funded centers that together comprise the UMAging Initiative. In six aims the AC will: 1) Leverage expert dementia resources and skills focused in each Core; 2) Maintain cohesive interplay across the Cores; 3) Sustain existing and build new local and regional partnerships; 4) Sustain existing and build further national partnerships; 5) Promote efforts to address racial and ethnic disparities in ADRD; and 6) Develop next-generation leaders through diverse research and training opportunities. In its first cycle as an NIH-designated ADRC, the Michigan ADRC met its milestones due, in part, to a proactive AC that helped build key state-wide partnerships. Benefitting from close links to the many complementary NIA-funded programs on our campuses, the outstanding additional resources of all three universities, and continuing philanthropic success, the Michigan ADRC is well-positioned to further enrich innovative dementia research, outreach, and training efforts, both regionally and nationally.