Michigan Alzheimer's Disease Core Center

整体 摘要 密歇根州阿尔茨海默病核心中心（密歇根州ADCC）旨在促进和加强创新 阿尔茨海默病（AD）和相关痴呆症的研究，长期目标是开发针对性的 治疗这些具有挑战性的疾病。该中心将建立在现有的深层基础设施和研究基础上， 密歇根大学（UM）在痴呆症和衰老研究方面的优势。密歇根州ADCC将 强调寻求识别、理解和调节非β-淀粉样蛋白因子的研究， AD和其他痴呆症的脑功能障碍和神经退行性变。这一重点的理由是， 虽然最近的进展已经确定了β-淀粉样蛋白在AD中的核心作用，但许多潜在的可改变因素 除了β-淀粉样蛋白外，它还导致脑功能障碍和变性，但人们对此知之甚少。的 密歇根州ADCC将利用在脑成像，痴呆症风险识别和 神经退行性蛋白质病的机制研究，以及预测性大数据分析， 实现这一目标。作为一个真正的区域中心，密歇根州ADCC将促进整个UM的研究 通过与我们的合作伙伴大学密歇根州立大学合作， 大学和韦恩州立大学，并在全国各地通过与其他NIA赞助的合作， AD中心（ADC）和程序。密歇根州ADCC有四个目标：1）培养，催化和执行 研究AD和相关神经退行性疾病的最高潜在影响; 2）促进区域 通过科学和技术合作， 3）提供广泛的痴呆症培训和研究机会， 通过创新的教育和指导工作，护理专业人员、科学家和学生;以及4） 与其他ADC，NACC和其他多中心研究工作合作，使该领域更接近 有效的治疗方法。将确保成功实现这些目标 通过六个核心（行政;临床;数据管理和统计; 神经病理学;外展和招聘;和研究教育组成部分），并通过关闭 与相关项目的合作，包括UM蛋白质折叠疾病倡议，克劳德D。胡椒 美国老年人独立中心、尤德尔帕金森病研究卓越中心和 密歇根州城市非裔美国人老龄化研究中心的更健康的黑人老年人中心。这些和 其他合作导致了新开发的重点对早期认知功能下降的检测， 服务不足的人群（底特律的非洲裔美国人）和新的潜在疾病生物标志物。的 中心广泛的初步组织和专家团队确保，在收到NIA指定， 密歇根州ADCC将在地区和国家两级产生直接影响， 更好地了解和治疗AD和相关形式的痴呆症。

OVERALL Abstract The Michigan Alzheimer’s Disease Core Center (Michigan ADCC) aims to foster and enhance innovative research in Alzheimer’s disease (AD) and related dementias with a long term goal of developing targeted therapies for these challenging disorders. This center will build on the existing deep infrastructure and research strengths in dementia and aging research at the University of Michigan (UM). The Michigan ADCC will emphasize research that seeks to identify, understand, and modulate the non-ß-amyloid factors that contribute to brain dysfunction and neurodegeneration in AD and other dementias. The rationale for this focus is that while recent advances have defined a central role for ß-amyloid in AD, many potentially modifiable factors beyond ß-amyloid contribute to brain dysfunction and degeneration yet remain poorly understood. The Michigan ADCC will leverage established strengths in brain imaging, dementia risk identification and disclosure, mechanistic studies of neurodegenerative proteinopathies, and predictive Big Data analytics to achieve this objective. A truly regional center, the Michigan ADCC will promote research across the UM campus, throughout the state of Michigan via collaborations with our partner universities Michigan State University and Wayne State University, and across the nation through collaborations with other NIA-sponsored AD Centers (ADCs) and programs. The Michigan ADCC has four goals: 1) Foster, catalyze and perform research of the highest potential impact in AD and related neurodegenerative disorders; 2) Promote regional efforts to understand, diagnose and treat AD and related dementias through collaborative scientific and outreach efforts; 3) Provide a wide range of training and research opportunities in the dementias for health care professionals, scientists, and students through innovative educational and mentoring efforts; and 4) Collaborate with other ADCs, the NACC, and other multi-center research efforts to move the field closer to effective therapies for this group of devastating diseases. Success in achieving these goals will be ensured through the fully integrated activities of six cores (Administrative; Clinical; Data Management and Statistical; Neuropathology; Outreach and Recruitment; and Research Education Component ), and through close collaboration with related programs including the UM Protein Folding Diseases Initiative, Claude D. Pepper Older Americans Independence Center, Udall Center of Excellence for Parkinson’s Disease Research, and Healthier Black Elders Center of the Michigan Center for Urban African American Aging Research. These and other collaborations have led to newly developed emphases on the detection of early cognitive decline in an underserved population (African Americans in Detroit) and on novel potential biomarkers of disease. The Center’s extensive preliminary organization and teams of experts ensure that, upon receiving NIA designation, the Michigan ADCC will have an immediate impact, both regionally and nationally, in enhancing research to better understand and treat AD and related forms of dementia.