Console Replacement and Upgrade of 9.4 Tesla Animal Instrument

项目摘要/摘要 这项提议的目的是取代目前功能失调、无人支持和停产的瓦里安 独特的9.4特斯拉/31厘米口径仪器上的“控制台”(即所有射频、梯度和数字电子设备) 到磁共振研究中心(CMRR)的中小型动物模型研究。到期 瓦里安于2010年被安捷伦技术公司收购，并终止了磁共振 安捷伦技术公司的业务/服务三年后，此控制台不再受支持。这个9.4 特斯拉(T)核磁共振仪是世界上第一台用于动物模型研究的水平孔扫描仪 在动物扫描仪以≤4.7T运行的时候，如此高的磁场。它一直是最有成效的 在CMRR的工具，导致了大量的新技术和重要出版物。许多动物 由美国国立卫生研究院11项有效拨款资助的成像项目继续依赖于这一工具。主机更新换代 以避免危及这些项目的成功，并支持未来的动物 在CMRR的高生产率环境中进行基于模型的研究。 CMRR的9.4T/31厘米口径系统在大量动物项目中一直发挥着至关重要的作用 在我们过去的生物技术研究中心内进行的模型P41和P30资助。它仍然被定为一部 在我们最近资助的BTRC P41 EB02706以及许多现在和过去的R01和U01赠款中发挥关键作用 来自美国国立卫生研究院。然而，我们直到最近才得以维护的仪器目前 对质子成像研究功能失调，对其他多核的生存能力也达到了极限 申请。 瓦里安终止为公司，随后停止对瓦里安游戏机和 安捷伦技术公司的系统使包括我们在内的所有瓦里安用户处于非常困难的长期和 站不住脚的地位。随着问题和故障的出现并在仪器上积累，仍有几个 随着瓦里安工程师被解雇，备件消失，承诺和修复的能力也没有得到解决 安捷伦和相关供应商的这些问题消失了。已经有许多瓦里安用户迁移到 游戏机主要由Bruker提供。我们的9.4特斯拉仪器已经到了一个临界点，类似的 现在需要更换控制台，以继续标志着这种动物历史的生产力 模型磁共振扫描仪。 因此，在这笔HEI赠款中寻求1,328,035美元的资金，用于将过时的9.4T控制台更换为 来自Bruker的集成且完全受支持的控制台。

PROJECT SUMMARY/ABSTRACT The aim of this proposal is to replace the currently dysfunctional, unsupported, and discontinued Varian “console” (i.e., all RF, gradient, and digital electronics) on a unique 9.4 Tesla/31 cm bore Instrument dedicated to small to medium size animal model studies at the Center for Magnetic Resonance Research (CMRR). Due to Varian being taken over by Agilent Technologies in 2010 and the termination of the magnetic resonance businesses/service by Agilent Technologies three years later, this console is no longer supported. This 9.4 Tesla (T) NMR instrument is the world’s first horizontal bore scanner established for animal model studies at such a high magnetic field at a time when animal scanners operated at ≤ 4.7T. It has been the most productive instrument at CMRR, resulting in a large number of new technologies and important publications. Many animal imaging projects funded by eleven active NIH grants continue to rely on this instrument. A console replacement is urgently needed in order to avoid jeopardizing the success of these projects, and support future animal model based research in the highly productive environment of the CMRR. CMRR’s 9.4T/31 cm bore system has always played a crucial role in a large number of projects on animal models conducted within our past Biotechnology Research Center P41 and P30 grants. It is still slated for a critical role in our recently funded BTRC P41 EB02706, and in numerous present and past R01 and U01 grants from the NIH. However, the instrument, which we have been able to maintain until recently, is currently dysfunctional for proton imaging studies, and has also reached limits of its viability for other multinuclear applications. The termination of Varian as company and subsequent cessation of all MR support for Varian consoles and systems by Agilent Technologies left all Varian users, including us, in a very difficult and in the long-term an untenable position. As problems and failures emerged and accumulated on the instrument, several remained unresolved as Varian engineers were laid off, spare parts disappeared, and a commitment and the ability to fix these problems in Agilent and associated vendors vanished. Already many Varian users migrated to the consoles provided mainly by Bruker. Our 9.4 Tesla instrument has reached a critical point where a similar console replacement is now needed to continue the productivity that has marked the history of this animal model MR scanner. Therefore, US$1,328,035 funding is sought in this HEI grant for replacing the outdated 9.4T console, with an integrated and fully supported console from Bruker.