Einstein/Rwanda/DRC Consortium for Research in HIV/HPV Malignancies

摘要 在本次U 54中，我们建议建立一个HPV/HIV相关的艾滋病研究中心， （人权高专办）作为卢旺达民主共和国境内各机构和调查人员的伙伴关系， 刚果（DRC）和美国（US），综合，跨学科的重点是 HIV/HPV相关恶性肿瘤。人权事务委员会计划协调和 HPV相关研究和能力建设综合计划（发展核心） PLWH中的癌症发展核心的目标是培养一批初级和中级干部， 水平的研究人员谁将利用该中心开发的资源，以促进研究， 卢旺达和刚果民主共和国（DRC）的HPV/HIV相关恶性肿瘤。 初级和中级研究人员的发展将通过学徒制完成 在这种模式中，他们与一位经验丰富的研究人员配对， 研究方案或试点项目的执行。指导将为每个人量身定制 受训人员，根据其先前的培训、研究经验、兴趣和研究 项目此外，还将利用同行评审的试点赠款计划， 开发专门针对HPV/HIV相关癌症的研究项目。的 发展核心将由三名独立资助的非洲调查人员领导 因此，研究人员为ESI提供了榜样，这些榜样已经解决了类似于 他们自己的和强有力的例子，以遵循/学习。除核心董事外， 导师将与学员一起参与主要的研究项目和潜在的试验项目。

ABSTRACT In this U54, we propose to establish an HPV/HIV-Associated Malignancy Research Center (HAMRC) as a partnership of institutions and investigators in Rwanda, the Democratic Republic of Congo (DRC) and the United States (US), with an integrated, trans-disciplinary focus on HIV/HPV-associated malignancies. The HAMRC is planned to have a coordinated and integrated program of research and capacity-building (Developmental Core) in HPV-related cancers in PLWH. The aim of the Developmental Core is to develop a cadre of junior and mid- level researchers who will utilize the resources developed by the Center to catalyze research in HPV/HIV-associated malignancies in Rwanda and the Democratic Republic of Congo (DRC). This development of junior and mid-level researchers will be done through an apprenticeship model in which they are paired with an experienced investigator in the development and execution of a research protocol or a pilot project. Mentoring will be individually tailored for each trainee, building on his or her prior training, research experience, interests and research projects. In addition, a peer-reviewed pilot grants program will be utilized to stimulate development of research projects specifically in HPV/HIV associated cancers. The Developmental Core will be led by three African investigators who are all independently funded researchers, thus, providing the ESIs with role models who have navigated challenges similar to their own and strong examples to follow/learn from. In addition to the Core Directors, a team of mentors will work with the trainees in the major research projects and potential pilot projects