Biopsychosocial predictors of obesity during the first 2 years of life

项目摘要 儿童肥胖症的流行是一个重大的公共健康危机。超重儿童 与他们的同龄人相比，他们经历了更多的健康和心理社会问题 这些问题很可能会伴随着他们进入青春期和成年期。在这 建议，我们描述了一项关于儿童肥胖风险早期发展的研究。风险 儿童早期肥胖可能由多种生理、心理和心理因素决定 在婴儿期可以观察到的社会因素。我们提出了一个概念模型，一个 生物心理社会模型，关注肥胖风险早期发展的几个关键因素 生物、心理和社会因素。使用一支经验丰富的调查团队， 多学科，我们建议用一种创新的、多方法的、 从产前开始对婴儿及其家人(n=300)进行的纵向研究 在生命的头两年解决这些因素。我们的两个主要目标集中在 了解(1)预测婴儿出生后6个月体重增加的因素和(2) 体重增加的方式以及婴儿在喂养和非喂养时与母亲的社会互动 喂养环境预示着自我调节能力，以及随后在2岁时肥胖的风险。 对制定有针对性的预防和干预方案的重要影响 在体重开始增加之前，在发育早期可能被利用的家庭和儿童 这一点很难逆转。

Project Summary The prevalence of childhood obesity is a significant public health crisis. Overweight children experience significantly more health and psychosocial problems compared to their same age peers and are likely to carry these problems with them into adolescence and adulthood. In this proposal, we describe a study of the early development of risk for obesity in childhood. The risk for obesity in early childhood is likely determined by multiple biological, psychological, and social factors that are observable in infancy. We propose a conceptual model, a biopsychosocial model, of the early development of risk for obesity that focuses on several key biological, psychological, and social factors. Using an experienced team of investigators from multiple disciplines, we propose to investigate this model with an innovative, multi-method, longitudinal study of infants and their families (n = 300) beginning in the prenatal period that addresses these factors across the first two years of life. Our two key aims focus on understanding (1) factors that predict infant weight gain in the first 6 months of life and (2) the ways in which this weight gain and infant’s social interactions with mothers in feeding and non- feeding contexts predict self-regulation, and subsequent obesity risk at age 2. The study has important implications for the development of targeted prevention and intervention programs for families and children that may be utilized early in development, prior to the onset of weight gain that is difficult to reverse.