Filling a Void of Research (FAVOR) Training for Transplant Surgeons

项目总结/摘要 FAVOR T32名为“填补移植外科医生研究培训的空白”，将准备手术 住院医生在腹部和胸部移植手术的转化研究事业。此程序将 培训和激励一个独特的外科医生，科学家的干部，在床边翻译敏锐的观察，在 手术室，并在临床上进入新的假设，可以通过免疫学为重点询问 翻译研究该计划是独特的重点，服务于日益增长的需要，以培养下一代的 移植外科医生-科学家，可以为新兴的翻译和个性化领域做出贡献 药FAVOR的结构是为了扭转令人沮丧的趋势，导致只有1.8%的ASTS训练有素的外科医生 研究员成功地竞争了NIH-K系列奖项，尽管76%的人有动力花更多的时间在 研究（Englesbe等人，AJT 2010：10，191-193; Kirk & Feng，AJT 2011，11; 191-193）。培训内容包括 临床研究设计，统计计算和数据库管理的核心课程 研究，科学写作和临床研究的生物统计方法。FAVOR T32还包括 专业培训选修课，将根据长期目标和兴趣为每个学员量身定制。一 来自UCSF的外科实习生的小骨干，所有培训补助金合格且高度多样化（约40% URM， 50%的女性），将被选中为FAVOR。我们亦会邀请其他学术机构的学员， 竞争性申请培训名额，受训人员将投入两年全日制， 临床职责，研究教育和培训。每年一个实习生名额也将有资格 参加1-2年的临床/转化医学学位课程。学员将准备应用他们的 培训，以加深对免疫系统的理解，以及开发新的，基于免疫的 与外科手术相关的诊断学、病理学、治疗学和临床方法， 结果。在该计划中，他们还将学习如何开发和利用临床数据库， 将手术结果与病理学和免疫学数据相结合。FAVOR的NIH资助的教师，与 在免疫学和转化研究方面的杰出记录，已被特别挑选出来，以激励 并指导学员进行翻译指导研究，从每个学院中选择2名导师/学员， 临床和科学导师库。培训后的职业咨询和指导将有助于安排到 为FAVOR学员提供有声望的研究金和学术教职。FAVOR的全国影响 该计划将通过一个具有全面临床经验的受训者群体的科学成熟来实现 专业知识和杰出的转化科学，具有应用转化免疫学的能力， 器官移植接受者

PROJECT SUMMARY/ABSTRACT The FAVOR T32 titled “Filling a Void of Research Training for Transplant Surgeons” will prepare surgical residents for translational research careers in abdominal and thoracic transplant surgery. This program will train and inspire a unique cadre of surgeon-scientists to translate astute observations at the bedside, in the operating room, and in the clinic into novel hypotheses that can be interrogated through immunology-focused translational research. This program is uniquely focused, serving a growing need to train the next generation of transplant surgeon-scientists that can contribute to the burgeoning field of translational and personalized medicine. FAVOR is structured to reverse the dismal trend resulting in only 1.8% of ASTS trained surgical fellows successfully competing for NIH-K series awards, despite 76% being motivated to spend more time in research (Englesbe et al., AJT 2010:10, 191-193; Kirk & Feng, AJT 2011, 11; 191-193). The training includes core courses in Designing Clinical Research, Statistical Computing and Database Management in Clinical Research, Scientific Writing, and Biostatistical Methods for Clinical Research. The FAVOR T32 also includes specialized training electives, which will be tailored to each trainee based on long-term goals and interests. A small cadre of surgical trainees from within UCSF, all training grant eligible and highly diverse (~40% URM, 50% female), will be selected for FAVOR. We will also invite trainees from other academic institutions by competitive application for training slots, where trainees will dedicate two full-time years, without significant clinical responsibilities, towards research education and training. One trainee slot/year will also be eligible to enroll in a 1-2 year degree course in Clinical/Translational Medicine. Trainees will be prepared to apply their training to deepen understanding of the immune system, as well as developing new, immune-based diagnostics, prognostics, therapeutics and clinical approaches that are relevant to surgical procedures and outcomes. While in the program they will also learn how to develop and draw upon clinical databases that integrate surgical outcomes with data from pathology and immunology. FAVOR's NIH-funded faculty, with distinguished track records in immunology and translational research, have been specially selected to inspire and guide trainees in translational mentored research, with selection of 2 mentors/trainee from each of the clinical and scientific mentor pools. Post-training career advice and guidance will facilitate placement into prestigious fellowships and academic faculty positions for FAVOR trainees. The national impact of the FAVOR program will be realized through the scientific maturation of a trainee group with comprehensive clinical expertise and outstanding translational science, with the ability to apply translational immunology to benefit organ transplant recipients.