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NMR Core

NMR Core
核磁共振核心
批准号：
10653256
负责人：
ANGELA M. GRONENBORN
金额：
$150.08万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
项目状态：
未结题
起止时间：
2022-07-01 至 2027-04-30
来源：
https://reporter.nih.gov/project-details/10653256
关键词：
CapsidCell NucleusCellsCommunitiesComplexData AnalysesDetectionDiseaseEnvironmentEquipmentFluorineFrequenciesFutureGoalsHIVHIV-1InstitutionIntegraseIntegrase InhibitorsIntegration Host FactorsMagicMapsMeasurementMeasuresMethodologyMethodsMolecular ConformationNMR SpectroscopyNatureNuclearNuclear ImportPhysiologicalPositioning AttributeProteinsProtocols documentationRecombinant ProteinsResearchResearch PersonnelResolutionResourcesSavingsSiteSpin LabelsStructureTechnologyTimeWorkbiophysical propertiescell typedata acquisitiondesignexperimental studyin vivoinhibitorinnovationinsightinstrumentationmagnetic fieldnew technologyprotein structurescreeningsolid statesolid state nuclear magnetic resonancestructural biologytrafficking

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中文摘要
翻译
核磁共振岩心 NMR核心的总体目标是为PCHPI研究人员提供最先进的能力， HIV-1蛋白及其复合物的结构和动力学水平表征。为了实现这一目标， 我们将利用一流的仪器资源，创新的实验方案， 在过去十年中发展的专业知识。具体目标是：（一）支持PCHPI项目和额外的 通过为HIV-1研究提供尖端的固态NMR能力，为合作者提供中心，以及ii）开发 用于HIV-1研究的细胞内溶液和固态19 F NMR。NMR Core开发的新技术 将对HIV-1的细胞结构生物学产生重大影响。
英文摘要
NMR Core The overall goal of the NMR Core is to provide state-of-the art capabilities for PCHPI researchers, for atomic- level characterization of structure and dynamics of HIV-1 proteins and their complexes. To accomplish this goal, we will take advantage of superb instrumentation resources, innovative experimental protocols, and unique expertise developed during the past decade. Specific aims are designed to i) support PCHPI projects and extra- center collaborators by providing cutting-edge solid-state NMR capabilities for HIV-1 research, and ii) develop in-cell solution and solid state 19F NMR for HIV-1 research. The novel technologies developed by the NMR Core will have major impact on HIV-1 cellular structural biology.
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Molecular, Cellular and Behavioral Impact of the R203W PACS1 Syndrome Mutation
Administrative Core
Pittsburgh Center for HIV Protein Interactions (PCHPI)
Pittsburgh Center for HIV Protein Interactions (PCHPI)
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