Natural Killer (NK) Cells and Development of Atherosclerosis: Cellular and Molecular Mechanisms
Natural Killer (NK) Cells and Development of Atherosclerosis: Cellular and Molecular Mechanisms
批准号:
nhmrc : 1068500
负责人:
A/Pr Peter Tipping
金额:
$48.65万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2016-12-31
中文摘要
动脉粥样硬化,即脂肪和白细胞在血管壁的积聚,是心脏病发作、中风和死亡的主要原因。降胆固醇药物只能降低40%的风险。靶向促进炎症的细胞是进一步降低风险的一种方法。我们已经证明,一种称为自然杀伤细胞(NK)的特定细胞类型在动脉粥样硬化的发展中起着重要作用。我们的目的是了解这些细胞如何促进动脉粥样硬化的发展。
英文摘要
Atherosclerosis, the accumulation of fat and white cells in the blood vessel wall is the major cause of heart attacks, stroke and death. Cholesterol lowering drugs reduce the risk by only 40%. Targeting cells that promote inflammation is one approach to further reduce risk. We have shown that a specific cell type called a natural killer (NK) cells contributes greatly to development of atherosclerosis. Our aim is to understand how these cells promote development of atherosclerosis.
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