Exercise-induced Legacy Health Benefits on Cardiometabolic Risk Factors in Aging Adults with Prediabetes

摘要 运动训练产生实质性的健康益处，总结在身体活动指南咨询 委员会报告，并纳入2008年和2018年美国人身体活动指南。 尽管众所周知的好处，太少的人采取运动作为一种健康维护策略。因此，在本发明中， 确定中年时期相对适度的运动训练是否会导致持续的 随着个人进入老年组（遗留效应），健康益处是公共卫生和临床的 重要性作为家长R21试图确定是否一个相对较短的六个月的运动干预， （STRRIDE-PD）产生持续的，遗留的健康影响十年后，这项拟议的补充将 同时在一个以社区为基础的队列中调查（ESTA校友心脏研究; UNCAHS）是否自我- 定向锻炼行为也与长期健康状况有关。因此，拟议的补编将 通过将研究结果的普遍性扩展到以下个体来增强亲本R21的重要性： 由于其风险因素或病史状态，不符合STRRIDE研究的资格。 与STRRIDE-PD团聚队列匹配，来自UNCAHS的200名年龄和性别匹配的参与者 谁已经报告了他们的无监督运动行为将被邀请完成平行评估， 心肺功能和心脏代谢危险因素。通过补编将联合国人类住区协调中心纳入其中， 允许我们比较监督运动训练计划的遗留影响，以自我指导的运动， 以社区为基础的队列。总的来说，母R21和拟议补充将提供独特的 深入了解中年和长期体育活动行为的生物学和心理学基础 心脏代谢健康状况。

Abstract Exercise training produces substantial health benefits, summarized in the Physical Activity Guidelines Advisory Committee Report and incorporated into the 2008 and 2018 Physical Activity Guidelines for Americans. Despite the well-known benefits, too few individuals adopt exercise as a health maintenance strategy. Thus, determining whether a relatively modest duration of exercise training in middle age can lead to sustained health benefits as individuals progress into older age groups (legacy effects) is of public health and clinical importance. As the parent R21 seeks to determine whether a relatively short six-month exercise intervention (STRRIDE-PD) produces sustained, legacy health effects ten years later, this proposed supplement will simultaneously investigate in a community-based cohort (UNC Alumni Heart Study; UNCAHS) whether self- directed exercise behavior is also related to long-term health status. Thus, the proposed supplement will enhance the significance of the parent R21 by extending the generalizability of the findings to individuals who would not have qualified for the STRRIDE studies due to either their risk factor or medical history status. Matched to the STRRIDE-PD Reunion cohort, 200 age- and gender-matched participants from the UNCAHS who have reported on their unsupervised exercise behavior will be invited to complete parallel assessments of cardiorespiratory fitness and cardiometabolic risk factors. Integrating the UNCAHS via the supplement will allow us to compare the legacy effects of supervised exercise training programs to self-directed exercise in a community-based cohort. Taken together, the parent R21 and the proposed supplement will provide unique insight into the biological and psychological underpinnings of physical activity behavior in midlife and long-term cardiometabolic health status.