Core-001

MS CEPR研究资源核心B 总结 密西西比围产期研究卓越中心（MS）研究资源核心B的目标 CEPR）COBRE在第二阶段将继续为研究人员和受训人员提供最先进的 设备和技术专长需要进行他们的研究。在第1阶段， 已开发：动物和遥测，荧光激活细胞分选（FACS）和流式细胞术， 线粒体研究、共聚焦显微镜、儿科超声心动图、基因组学和统计学 分析。UMMC和MS CEPR为这些子核心购买了最先进的新设备 眼镜蛇其中两个子核心现在是独立的收入中立的充电中心，儿科回声 和基因组学子核心。对于II期，增加了一个新的子核心，即临床研究子核心， 为研究项目负责人（RPL）和试点项目负责人（PPL）提供支持， 问题研究核心B的教职员工与RPL和PPL及其学员密切互动，并致力于 提供协调和合作的资源，以支持他们的研究。此外，核心B人员 在使用现有方法方面提供专家援助，但也可用于开发新的 方法和测定，现有测定的改进，提供结果和数据的解释，提供 设备和分析工具的培训、技术支持和监督。MS CEPR子核心是 独特的，他们的专业知识是不提供在校园内的其他COBREs（肾脏和代谢 疾病研究COBRE（P20 GM 104357）（CMDR，目前处于第2阶段）或精神病学中心 Neurosciences COBRE（P30 GM 103328，现已完成第3阶段）或南密西西比大学 INBRE计划，但他们的研究人员可以使用。研究资源核心B的具体目标 第二阶段包括以下内容：1）继续支持和调整最先进的研究服务，以满足 RPL和PPL的需求，并促进新研究者和中心成员的招募; 2） 继续为所有人提供最先进设备的使用、维护、培训和监督 内部和外部的研究人员、工作人员和学生; 3）优化所有检测和核心服务， 改进现有的分析和服务，并协助解释结果和数据; 4） 为核心B中的所有子核心开发符合联邦资助的充电中心业务模型 提供核心B服务、设备和设施可持续性的指导方针。核心B的服务包括 这是成功完成项目1-3所述研究的绝对必要条件，也是一笔财富 PPL也是。此外，其他研究人员，无论是内部和外部，都可以访问研究 资源核心B服务。

MS CEPR RESEARCH RESOURCES CORE B SUMMARY The goal of the Research Resources Core B of the Mississippi Center of Excellence in Perinatal Research (MS CEPR) COBRE in Phase 2 is to continue to provide investigators and trainees with access to state-of-the-art equipment and technical expertise needed to perform their research. During Phase 1, new Sub-cores were developed: Animal and Telemetry, Fluorescence-Activated Cell Sorting (FACS) and Flow Cytometry, Mitochondrial Research, Confocal Microscopy, Pediatric Echocardiography, Genomics, and Statistical Analyses. New state-of-the-art equipment was purchased for these Sub-cores by UMMC and the MS CEPR COBRE. Two of these Sub-cores are now independent revenue neutral recharge centers, the Pediatric Echo and Genomics Sub-cores. For Phase 2, a new sub-core was added, the Clinical Research Sub-core, that provides support for research project leaders (RPLs) and pilot project leaders (PPLs) in performing clinical studies. Faculty and staff of Core B interact closely with RPLs and PPLs and their trainees, and are dedicated to providing coordinated and collaborative resources to support their research. In addition, Core B personnel provide expert assistance in the use of existing methods but are also available for development of new methods and assays, improvement of existing assays, provide interpretation of results and data, provide training, technical support, and supervision for equipment and analytical tools. The MS CEPR Sub-cores are unique and their expertise is not available in the other COBREs on campus (the Cardiorenal and Metabolic Diseases Research COBRE (P20 GM104357) (CMDR, now in Phase 2) or the Center for Psychiatric Neurosciences COBRE (P30 GM103328, now completed Phase 3)) or the University of Southern Mississippi INBRE program, but are available to their investigators. The Specific Aims of the Research Resources Core B in Phase 2 include the following: 1) To continue to support and adapt state-of-the-art research services to meet the needs of RPLs and PPLs and facilitate recruitment of new investigators and center members; 2) To continue to provide access to, maintenance, training and supervision in use of state-of-the-art equipment for all investigators, staff and students, internal and external; 3) To optimize all assays and core services, to provide improvement in existing assays and services, and to assist in the interpretation of results and data; 4) To develop a recharge center business model for all Sub-cores in Core B that is compliant with federal funding guidelines to provide sustainability of Core B services, equipment, and facilities. The services of Core B are absolutely necessary for the successful completion of the studies described in Projects 1-3 and will be an asset to PPLs as well. In addition, other investigators, both intramural and extramural, have access to the Research Resources Core B services.