Shared Resource 01: Biomedical Informatics (BISR)

项目摘要-生物信息学共享资源(BISR) BISR是一个基本的共享资源，支持生物信息学和 计算生物学需求，从下一代测序(NGS)到种群中的数据管理 科学研究。BISR隶属于BMI部门，其目标是利用各种信息学 服务，从组学数据集分析到以患者/参与者为中心的数据工具、访问、 以及管理工具和流程。BSR的具体目标是：1)提供最先进的 生物信息学和计算生物学服务；以及2)向OSUCCC调查人员提供服务， 支持异质和多维生物医学的专业知识和技术平台 数据管理要求。在当前的赠款周期中，Kevin Coombes博士(TT)和Lang Li博士(CB) 接替菲利普·佩恩博士和杰弗里·帕文博士，担任BISR的领导人。在本供资周期内，a 为生物医学信息学系(BMI)和 OSUCCC将在BISR内以每年10%的速度支持5名教师，当他们过渡到补助金资助时，为期3年 以滚动为基础，为OSUCCC成员和/或提供免费的、以癌症为重点的生物信息学工作 专注于癌症的研究人员。BISR的其他主要变化包括支持增强 基因组学共享资源(GSR)将新开发的共享服务与全国儿童 医院(NCH)；并增加了支持涉及单细胞测序数据的研究的能力，长期阅读 (第三代)测序、代谢组学和元基因组学。BISR增加了五名新的教职员工以支持 (1)药物敏感性预测的计算优化；(2)蛋白质组学和功能 DNA非编码区的注释(Zhang)，(3)代谢组学和元基因组学(Mathe)，(4)单细胞 测序(Ma)，以及(5)长读测序(Au)。BISR支持的Biosecimen服务共享资源 (BSSR)项目(全面癌症护理[TCC]和肿瘤学研究信息交流网络[ORIEN]) 通过建立包含未识别数据的患者记录的数据仓库。在本供资周期内， BISR支持115个出版物(25&>10个影响因子)、134个用户和32个NCI赠款，包括5个P01、2个P50、 13个R01，3个R21，1个R50，2个U01，1个U10，1个UG1，涉及所有五个项目的成员。在下一笔赠款上 BISR将加强“整合”服务，例如整合不同来源的组学和 临床数据。BISR将是免疫监测和发现平台(IMDP)的关键部分，IMDP是 促进复杂免疫肿瘤学项目共享资源之间的互动的方法。一年一度的 BISR的预算是1,122,279美元，而CCSG的请求是106,905美元。因此，BISR利用广泛的 机构支持，只从CCSG基金寻求9.5%的支持。

PROJECT SUMMARY – BIOINFORMATICS SHARED RESOURCE (BISR) The BISR is an essential shared resource that supports a wide range of studies with bioinformatics and computational biology needs, ranging from next generation sequencing (NGS) to data management in population science studies. Housed within the Department of BMI, the BISR's goal is to leverage a variety of informatics services, ranging from analysis of omics datasets to patient/participant-centered data instrumentation, access, and management tools and processes. The Specific Aims of the BSR are to: 1) Provide state of the art bioinformatics and computational biology services; and 2) Provide OSUCCC investigators with services, expertise and access to technology platforms in support of heterogeneous and multi-dimensional biomedical data management requirements. Over the current grant cycle, Drs. Kevin Coombes (TT) and Lang Li (CB) assumed leadership of BISR, replacing Drs. Philip Payne and Jeffrey Parvin. During the current funding cycle, a Memorandum of Understanding (MOU) was established for the Department of Biomedical Informatics (BMI) and the OSUCCC to support 5 faculty at 10% per year for 3 years within BISR as they transition to grant funding, on a rolling basis, to provide non-chargeable, cancer focused bioinformatics work for OSUCCC membership and/or cancer focused researchers. Additional major changes for BISR include supporting the enhancement of the Genomics Shared Resource (GSR) to incorporate newly developed shared services with Nationwide Children's Hospital (NCH); and added capabilities to support studies involving data from single-cell sequencing, long-read (third generation) sequencing, metabolomics, and metagenomics. BISR has added five new faculty to support the areas of (1) computational optimization for drug sensitivity prediction (Cheng), (2) proteomics, and functional annotation of DNA non-coding regions (Zhang), (3) metabolomics and metagenomics (Mathe), (4) single-cell sequencing (Ma), and (5) long-read sequencing (Au). BISR supported Biospecimen Services Shared Resource (BSSR) projects (Total Cancer Care [TCC] and the Oncology Research Information Exchange Network [ORIEN]) by establishing a data warehouse of patient records with de-identified data. During the current funding cycle, the BISR supported 115 publications (25 > 10 impact factor), 134 users, and 32 NCI grants including 5 P01s, 2 P50s, 13 R01s, 3 R21s, 1 R50, 2 U01s, 1 U10, 1 UG1, involving members from all five programs. Over the next grant cycle, BISR will enhance services for “integromics”, e.g., the integration of disparate source of both omics and clinical data. BISR will be a critical part of the Immune Monitoring and Discovery Platform (IMDP), an overarching approach for fostering interactions among shared resources for complex immuno-oncology projects. The annual budget of the BISR is $1,122,279, yet the CCSG request is $106,905. As such, the BISR leverages extensive institutional support and seeks only 9.5% support from CCSG funds.