General Surgical Pathology

普通外科病理科为NIH临床中心提供临床外科病理学诊断服务，从而为整个NIH社区提供服务。应用的诊断方法包括苏木素和曙红组织学，以及辅助研究，如免疫组织化学、分子遗传学研究和基于组织的荧光原位杂交。临床医生在这一领域遇到的疾病过程范围很广，包括癌症、良性肿瘤、传染病、退行性疾病和衰老过程、发育障碍、心脏和循环系统疾病以及遗传性疾病。许多被评估的标本来自罕见或甚至未诊断的疾病患者的独特群体。因此，这些来自活组织检查和手术切除的临床组织，以及相应的患者临床信息，构成了该科临床工作人员开展协作研究项目的丰富资源。此外，在病理实验室广受好评的ACGME认证的培训计划中，它们也被用作解剖病理学住院医师培训的重要组成部分。在这一年里，我们参与了与混合性神经鞘瘤相关的神经外科研究项目，肾上腺癌对IL13受体表达的研究，以及间皮瘤移植和BAP1突变的研究。在过去的几年里，我们对PDL-1阳性的结肠癌、非皮肤黑色素瘤的病理和遗传学、融合肉瘤和癌，特别是结肠癌中罕见的NTRK和ALK基因融合进行了研究，并对这些肿瘤进行了详细的描述。最近，我们完成了一项关于鼻腔黑色素瘤的基因组学和PRAME抗原在不同家系的恶性肿瘤队列中的分布的大型研究。我们继续探索肉瘤和其他软组织肿瘤的融合和甲基化分类研究

The Section of General Surgical Pathology provides clinical surgical pathology diagnostic services to the NIH Clinical Center, and thereby to the entire NIH community. The diagnostic modalities utilized include hematoxylin and eosin-based histology, and adjunct studies such as immunohistochemistry, molecular genetic studies, and tissue-based fluorescence in situ hybridization. The breadth of disease processes encountered by clinicians in this Section is wide, and includes cancer, benign tumors, infectious diseases, degenerative diseases and the aging process, developmental disorders, diseases of the heart and circulatory system, and genetic diseases. Many of the specimens evaluated derive from unique populations of patients with rare or even undiagnosed diseases. Accordingly these clinical tissues from biopsies and surgical resections, along with the corresponding patient clinical information, comprise a resource rich for collaborative research projects for the clinical staff in the Section. In addition, they are utilized as an essential component in the training of Anatomic Pathology residents in the Laboratory of Pathology's well-regarded ACGME-accredited Training Program. During the year we participated in neurosurgical research project related to hybrid schwannomas, studies on adrenal carcinomas on IL13 receptor expression, and in projects on mesothelioma xenografts and BAP1 mutations. During the last years, we have studied PDL-1 positive colon cancers, pathology and genetics of non-cutaneous melanoma, and fusion sarcomas and carcinomas, especially, colon carcinoma finding infrequent NTRK and ALK gene involving fusions and characterized those tumors in detail. Lately we finished a large study on genomics of sinonasal melanoma and distribution of PRAME antigen in a large cohort of malignancies of different lineages. We continue exploring fusion and methylation classifier studies on sarcomas and other soft tissue tumors