Synthesis and Development of Trefoil Factor Peptides

三叶因子家族多肽(TFF1、TFF2和TFF3)在保护、维持和修复胃肠道以及乳腺癌的信号转导通路中起关键作用。因此，它们具有治疗或预防与粘膜损伤相关的各种胃肠道疾病的潜力。TFF多肽有一个保守的基序，包括三个二硫键，稳定了一个明确的三环结构，使人想起三叶草。尽管TFF肽的多种功能已被描述，但其分子水平上的机制仍然知之甚少。我们的工作集中在TFF成员的化学合成上，以克服这一多肽家族合成生产的公认瓶颈。这使我们能够评估假定的TFF受体和蛋白质伙伴，以及它们在这些肽在胃肠道疾病治疗潜力中的重要性，在胃肠道疾病中，粘膜生物学改变发挥着关键作用。我们的研究旨在更好地了解该多肽家族及其治疗胃肠道疾病的潜力。

Trefoil factor family peptides (TFF1, TFF2, and TFF3) are key players in protecting, maintaining, and repairing the gastrointestinal tract and in signaling pathways in breast cancer.. Accordingly, they have the therapeutic potential to treat or prevent a variety of gastrointestinal disorders associated with mucosal damage. TFF peptides share a conserved motif, including three disulfide bonds that stabilize a well-defined three-loop-structure reminiscent of a trefoil. Although multiple functions have been described for TFF peptides, their mechanisms at the molecular level remain poorly understood. Our work is focused on the chemical synthesis of members of the TFF to overcome the recognised bottleneck of synthetic production of this peptide family. This allows us to evaluate putative TFF receptors and protein partners and their importance in the therapeutic potential of these peptides in gastrointestinal disorders where altered mucosal biology plays a crucial role. Our research aims to better understand this peptide family and its therapeutic potential for the treatment of gastrointestinal disorders.