An Imaging Repository for the Cerebrovascular Disease Knowledge Portal (iCDKP)

项目摘要 中风是世界上第二大死亡原因。到2030年，估计全球将有1.224亿人 而仅在美国，与中风相关的医疗费用预计将超过1800亿美元。此外，委员会认为， 中风本身只是脑血管病最急性的表现，它也会引起慢性 脑功能进行性恶化，包括血管对认知障碍和痴呆的影响 （VCID）。尽管迫切需要新的治疗方法，但导致脑缺血的精确生物学途径 和出血，大脑对损伤的反应，以及大脑的恢复能力仍然很差 明白成像提供了这些过程的关键和可量化的措施。如果不成像， 不可能描述受影响的大脑位置、涉及的脑组织数量或脑体积 肿胀/水肿。此外，同一患者随时间的连续图像捕获动态生理学，诸如 梗塞生长或出血生长，这两者对于研究损伤和恢复都是至关重要的。国际 中风遗传学联盟（ISGC）的成立是为了利用人类遗传学来识别新的生物学特征。 最终可以导致有效治疗中风的途径。事实上，候选药物治疗支持 通过人类遗传学的证据，更有可能获得FDA的批准。ISGC的 致力于大型统一数据集、开放数据共享和协作文化， 迄今为止，所有得到有力支持的常见中风风险基因中， 作为新疗法的基础进行研究。2017年，ISGC推出了脑血管疾病知识 门户（CDKP）（R24 NS 092983），以遵守的方式与研究界自由共享遗传数据 公平数据原则这种资源的一个主要局限是缺乏大脑图像。为此，建议 生物医学数据库合作协议（U24），我们将汇集大脑成像和遗传数据 根据FAIR数据原则，从估计30，000名中风患者中收集数据，并共享这些数据 根据FAIR数据原则。基于已建立的卒中神经影像表型库 （SNIPR）在华盛顿大学，我们的计划将把CDKP转化为成像CDKP（iCDKP）， 为全球社区提供一个单一的FAIR接入点，以获取遗传、表型和成像数据。 里程碑驱动的目标将：1）聚合来自国际范围内的高价值卒中成像数据集 研究者社区; 2）实施公平数据共享实践和程序; 3）参与研究 社区与仓库我们的团队由CDKP和SNIPR的PI领导，非常适合执行此项目 鉴于我们已经与国际中风研究界协商制定了这一建议， 确保广泛支持和最大限度地满足其预期需求。

PROJECT ABSTRACT Stroke is the world’s second-leading cause of death. By 2030 an estimated 122.4 million people world-wide will be affected while stroke-related medical costs in the US alone are projected to exceed $180 billion. Furthermore, stroke itself is only the most acute manifestation of cerebrovascular disease, which also causes chronic progressive deterioration in brain function, including vascular contributions to cognitive impairment and dementia (VCID). Despite a pressing need for novel treatments, the precise biological pathways that lead to brain ischemia and hemorrhage, the response of the brain to injury, and the brain’s capacity for recovery remain poorly understood. Imaging provides crucial and quantifiable measures of these processes. Without imaging it is impossible to characterize the location of the brain affected, quantity of brain tissue involved, or amount of brain swelling/edema. Furthermore, serial images of the same patient over time capture dynamic physiology such as infarct growth or hemorrhage growth, which are both crucial to studying injury and recovery. The International Stroke Genetics Consortium (ISGC) was founded to harness human genetics to identify novel biological pathways that can ultimately lead to effective treatments for stroke. Indeed, candidate drug treatments supported by evidence from human genetics are substantially more likely to achieve FDA approval. The ISGC’s commitment to large harmonized data sets, open data sharing and collaborative culture has led to the discovery of all of the robustly supported risk genes for common forms of stroke to date, many of which are already being studied as the basis for novel treatments. In 2017 the ISGC launched the Cerebrovascular Disease Knowledge Portal (CDKP) (R24NS092983) to share genetic data freely with the research community in a manner adherent to FAIR Data Principles. A major limitation of this resource is the absence of brain images. For this proposed biomedical data repository cooperative agreement (U24) we will aggregate brain imaging and genetic data according to FAIR data principles from an estimated 30,000 individuals with stroke and share these data according to FAIR data principles. Building on the established Stroke Neuro-Imaging Phenotype Repository (SNIPR) at Washington University, our program will transform the CDKP into the imaging CDKP (iCDKP), providing the global community with a single FAIR access point to genetic, phenotypic, and imaging data. Milestone-driven aims will: 1) Aggregate high value stroke imaging datasets from across the international investigator community; 2) Implement FAIR data sharing practices and procedures; 3) Engage the research community with repository. Our team, led by the PIs for CDKP and SNIPR is well-situated to execute this project given that we have developed this proposal in consultation with the international stroke research community to ensure broad support and maximum response to their anticipated needs.