Cancer Prevention and Control Research Program

项目总结/摘要 马基癌症中心（MCC）的癌症预防和控制（CP）研究计划培养高 影响，基于人口和社区参与的研究，其总体目标是减少癌症 在肯塔基州的差距。CP研究跨越人口科学翻译管道， 了解风险因素和干预目标，开发和测试新的干预措施，研究 传播循证干预措施并将其付诸实践的过程。影响力 科学贡献包括人类乳头瘤病毒和患者生存的遗传关联， 口咽癌，及时对新型无烟烟草产品进行监管和政策研究， 减少致癌环境接触的创新干预措施， 农村癌症幸存者的生活质量结果，以及预防肝炎的社区实施试验 C传播，并在整个社区实施癌症预防和筛查指南 肯塔基州和阿巴拉契亚。CP的影响还延伸到肯塔基州和全国的公共卫生政策， 提高戒烟和肺癌筛查相关的护理标准。CP计划 结合这些优势，以解决三个目标：提高对风险因素和干预的理解 癌症预防和控制的目标（目标1）;制定和测试跨部门干预措施的功效 癌症控制连续体（目标2）;研究循证 （目标3）。CP计划已经通过大量战略投资进行了改造， 导致了新的领导和注入多个招聘，扩大了广度和深度， 计划研究，结合长期计划成员的持续成功。该计划的 同行评审的资金增加了50%，NCI的资金到目前为止大幅增长了567% 占同行评审资金的33%，而2017年为7%。该计划的成熟是显而易见的， 临床试验累积增加24%，通过授予NCI P01和UH 3多名研究者， 机构赠款和唯一的NCI T32侧重于农村癌症差异。CP调查人员高度 参与并响应MCC集水区居民的需求，并参与 与社区合作，开展方案研究，解决MCC的流域研究优先事项 外展和参与。因此，CP计划对于实现MCC的总体使命， 通过研究，预防， 治疗、教育和社区参与。

PROJECT SUMMARY/ABSTRACT Markey Cancer Center’s (MCC) Cancer Prevention and Control (CP) Research Program fosters high- impact, population-based and community-engaged research with the overarching goal of reducing cancer disparities in Kentucky. CP research spans the population science translation pipeline from advancing understanding of risk factors and intervention targets, to developing and testing new interventions, to studying the process of dissemination and implementation of evidence-based interventions into practice. Impactful scientific contributions include genetic associations of human papillomavirus and patient survival in oropharyngeal cancer, timely regulatory and policy research on novel smokeless tobacco products, trials of innovative interventions to reduce carcinogenic environmental exposures, trials of interventions to promote quality of life outcomes among rural cancer survivors, and community implementation trials to prevent hepatitis C transmission and implement cancer prevention and screening guidelines in communities throughout Kentucky and Appalachia. CP impact also extends to public health policy within Kentucky and nationally, and in advancing standards of care related to tobacco cessation and lung cancer screening. The CP Program combines these strengths to address three Aims: Advance the understanding of risk factors and intervention targets for cancer prevention and control (Aim 1); Develop and test the efficacy of interventions across the cancer control continuum (Aim 2); Study the dissemination and implementation of evidence-based interventions (Aim 3). The CP Program has been transformed by substantial strategic investments that have led to new leadership and by the infusion of multiple recruitments that have expanded the breadth and depth of program research, combined with the continued success of long-standing program members. The program’s peer-reviewed funding has increased by 50%, and NCI funding has grown dramatically by 567% to now comprise 33% of peer-reviewed funding, compared to 7% in 2017. The maturation of the program is evident in a 24% increase in clinical trial accrual and by the awarding of NCI P01 and UH3 multi-investigator, inter- institutional grants and the only NCI T32 focused on rural cancer disparities. CP investigators are highly engaged with and responsive to the needs of MCC’s catchment area residents and are engaged in inter- programmatic research that addresses MCC’s catchment research priorities, in collaboration with Community Outreach and Engagement. Thus, the CP Program is integral to achieving the overall MCC mission to reduce the cancer burden with a focus on Kentucky and its most vulnerable populations through research, prevention, treatment, education and community engagement.