Cortical and subcortical chandelier cell pathophysiology and symptomatology in autism

摘要 这是女士的多样性补充阿德里安娜Pantoja，在UCD戴维斯一年级研究生。 女士Pantoja将致力于母基金目标2a的一些新方面：吊灯的作用 细胞在自闭症发病机制中的作用目标2a建议吊灯的数量（Ch） 细胞在海马结构的两个区域中发生差异性改变。潘托贾女士将进一步 这一目的是通过量化海马结构的第三和第四组分中的Ch细胞， 大脑下托复合体和内嗅皮层。下托复合体和内嗅皮层 与边缘系统的组成部分相互联系，边缘系统是调节 学习、记忆和情感，这些功能在ASD中被改变。 suplementee的职业目标是到2026年完成博士学位，然后执行 博士后培训，然后成为她自己的研究实验室的首席研究员。 在这两年的补助期间，Pantoja女士将申请F31少数民族补助金。 她将获得Martínez-Cerdeño博士的职业科学和专业指导， 加州大学戴维斯分校病理学教授，西班牙裔导师和外展领导者，以及 导师兰迪·哈格曼博士，MIND研究所的临床主任。

Abstract This is a diversity supplement for Ms. Adriana Pantoja, first year graduate student at UCD Davis. Ms. Pantoja will work in some novel aspects of aim 2a of the parent grant: Role of Chandelier cells in the pathogenesis of Autism. Aim 2a proposes that that the number of Chandelier (Ch) cells is differentially altered in two areas of the hippocampal formation. Ms. Pantoja will further this aim by quantifying Ch cells in the third and fourth components of the hippocampal formation, the subicular complex and the entorhinal cortex. The subicular complex and the entorhinal cortex are interconnected with the components of the limbic system that is fundamental for regulating learning, memory, and emotions, functions that are altered in ASD. The suplementee professional goal is to accomplish her PhD degree by 2026, and then perform postdoctoral training followed by becoming principal investigator of her own research laboratory. During the period of this two years supplement, Ms. Pantoja will apply for a minority F31 grant. She will receive career scientific and professional mentorship from Dr. Martínez-Cerdeño, Professor of Pathology at UC Davis and a leader in Hispanic mentorship and outreach, and co- mentor Dr. Randi Hagerman, clinical director of the MIND Institute.