Human Auditory Cortex Physiology

人类听觉皮层生理学 语音是我们听到的最重要的声音；然而，我们对这些刺激是如何产生的知之甚少 存在于人类的听觉皮质中。我们研究的目标是了解功能 人类大脑皮层中从事声音处理的区域的组织和连接 并研究听觉和视觉语音刺激在这些区域是如何表现的。这些实验 包括从清醒的大脑皮层直接电生理记录和电刺激 人类受试者接受顽固性癫痫的临床评估。 我们将通过测试一系列关于以下方面的具体假设来实现我们的目标：1)地点和功能 听觉皮层区域的特性，2)对语音刺激的诱发反应的方式 在这些领域内的表现和转换，3)视觉语音信息的影响和竞争 这些区域内皮层处理的背景噪声，以及4)功能联系和模式 这些领域之间的信息流。这些目标是由经验丰富的多学科人员追求的 使用直接调查方法的团队，以收集免费的人类生理和 解剖学数据。由此产生的测量结果不能使用非侵入性技术获得。我们 追求这些目标，相信对正常的基本结构和功能的知识 人类的听觉系统对于理解导致所有方面的损伤的机制是必不可少的 听力、言语和语言。

Human Auditory Cortex Physiology Speech sounds are the most important sounds that we hear; yet little is known about how these stimuli are represented within human auditory cortex. The goal of our research is to understand the functional organization and connections of those areas of human cerebral cortex that are engaged in sound processing and examine how auditory and visual speech stimuli are represented in these regions. These experiments involve direct electrophysiological recording from, and electrical stimulation of, the cerebral cortex of awake human subjects undergoing clinical evaluation of intractable epilepsy. We will pursue our goals by testing a series of specific hypotheses regarding: 1) the locations and functional properties of auditory cortical fields, 2) the manner in which evoked responses to speech stimuli are represented and transformed within these fields, 3) the influence of visual speech information and competing background noise on cortical processing within these fields, and 4) the functional connections and patterns of information flow between these fields. These objectives are pursued by an experienced multidisciplinary team using direct investigative methods in order to gather complimentary sets of human physiological and anatomical data. The resulting measurements cannot be obtained using non-invasive techniques. We pursue these objectives believing that knowledge of the fundamental structure and function of the normal human auditory system is essential to understanding mechanism that underlie impairment of all aspects of hearing, speech, and language.