Human Auditory Cortex Physiology

人类听觉皮层生理学

• 批准号: 7049101
• 负责人: Matthew A. Howard
• 金额: $ 56.22万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7049101
• 关键词: auditory cortex; brain electrical activity; brain mapping; clinical research; electrophysiology; evoked potentials; human subject; neural information processing; sound perception; speech recognition; speechreading

DESCRIPTION (provided by applicant): Human Auditory Cortex Physiology Speech sounds are the most important sounds that we hear; yet little is known about how these stimuli are represented within human auditory cortex. The goal of our research is to understand the functional organization and connections of those areas of human cerebral cortex that are engaged in sound processing and examine how auditory and visual speech stimuli are represented in these regions. These experiments involve direct electrophysiological recording from, and electrical stimulation of, the cerebral cortex of awake human subjects undergoing clinical evaluation of intractable epilepsy. We will pursue our goals by testing a series of specific hypotheses regarding: 1) the locations and functional properties of auditory cortical fields, 2) the manner in which evoked responses to speech stimuli are represented and transformed within these fields, 3) the influence of visual speech information and competing background noise on cortical processing within these fields, and 4) the functional connections and patterns of information flow between these fields. These objectives are pursued by an experienced multidisciplinary team using direct investigative methods in order to gather complimentary sets of human physiological and anatomical data. The resulting measurements cannot be obtained using non-invasive techniques. We pursue these objectives believing that knowledge of the fundamental structure and function of the normal human auditory system is essential to understanding mechanism that underlie impairment of all aspects of hearing, speech, and language.

描述（申请人提供）：人类听觉皮层生理学语音是我们听到的最重要的声音；然而，对于这些刺激是如何在人类听觉皮层中表现出来的，我们知之甚少。我们的研究目标是了解人类大脑皮层中参与声音处理的区域的功能组织和联系，并研究听觉和视觉语言刺激如何在这些区域表现出来。这些实验包括直接电生理记录和电刺激醒着的人类受试者的大脑皮层，进行难治性癫痫的临床评估。我们将通过测试一系列具体的假设来实现我们的目标：1)听觉皮层场的位置和功能特性，2)对语音刺激的诱发反应在这些场中表现和转换的方式，3)视觉语音信息和竞争背景噪声对这些场中皮层处理的影响，以及4)这些场之间的功能连接和信息流模式。这些目标是由一个经验丰富的多学科团队采用直接的调查方法，以收集人体生理和解剖数据的互补集。使用非侵入性技术无法获得测量结果。我们相信了解正常人类听觉系统的基本结构和功能对于理解听力、言语和语言各方面损伤的机制至关重要。