NERBL Core 1: Facility Management, Maintenance and Operations

项目概要-核心1 核心1（设施管理、维护和运营核心）的广泛、长期目标是 新英格兰地区生物安全实验室（NERBL）将确保针对以下方面的研究或任务 促进研究或应对具有大流行潜力的病原体和其他新出现的感染 (PPP/EI），安全、高效、严格地完成。虽然每天都有有形基础设施支持， 操作（建筑和实验室相关）和实验室/动物园活动通常是 由于各职能部门人员配置和专门知识不同，职能重复是一个 生物防护的基本原则因此，核心1的主要目标是确保NERBL工作人员 培训设施管理、维护和运营的核心能力，确保 关键职能的冗余，包括生物安全。与此核心相关的两个元素 （1）有形基础设施的可持续性，包括持续监测BSL-3遏制系统; BSL-3防护设施的去污、重新测试和认证; 根据关键现有设备和建筑系统的维修和生命周期更换计划 BSL-3/ABSL-3作业所需;以及紧急修理/更换基本设备， 运行NERBL所需的建筑系统;以及2）法规合规性，包括所有现有和 未来关于控制特定物剂和其他高致病性物剂的生物安保指令; 确认NERBL和工作人员遵守所有相关的环境健康和生物安全要求。 直接让所有员工参与物理设施基础设施的维护和相关合规性 通过这些活动，他们对NERBL成功的基本要素有了深刻的理解。 这也创造了一种真正的合作伙伴关系，其成功取决于所有人的参与 持份者为了实现这些目标，我们将培训和维持更多的设施管理人员， 维护和运营，创建和优化标准操作程序，确保安全可靠 NERBL的运作，并制定财政和资源管理计划，支持长期 研究活动的可持续性和成功，既响应了研究者发起的请求，又响应了公私伙伴关系/环境倡议 NIAID的具体优先事项。

PROJECT SUMMARY – CORE 1 The broad, long-range objective of Core 1 (Facility Management, Maintenance, and Operations Core) for the New England Regional Biosafety Laboratory (NERBL) is to ensure that research or tasks directed to promoting research on or responding to pathogens of pandemic potential, and other emerging infections (PPP/EI), are safely, efficiently, and rigorously accomplished. Although physical infrastructure support, daily operations (both building and laboratory related), and laboratory/vivarium activities are typically compartmentalized functions with separate staffing and specialized expertise, redundancy of functions is an essential tenet for biocontainment. As such, the primary goal of Core 1 is to ensure that NERBL staff are trained in core competencies for facility management, maintenance, and operation, ensuring redundancy of key functions, including biosafety, at all times. The two elements associated with this Core are: 1) sustainability of physical infrastructure, including continuous monitoring of BSL-3 containment systems; decontamination, retesting, and certification of BSL-3 containment facilities; preventive maintenance in accordance with a repair and lifecycle replacement plan for critical existing equipment and building systems necessary for BSL-3/ABSL3 operations; and emergency repair/replacement of essential equipment and building systems required for operating the NERBL; and 2) regulatory compliance, including all existing and future biosecurity directives related to control of select agents and other highly pathogenic agents; and confirming that the NERBL and staff adhere to all relevant environmental health and biosafety requirements. By directly engaging all staff in maintenance of physical facility infrastructure and associated compliance activities, they gain a deep understanding regarding foundational elements that underly success of the NERBL. This also creates a truly collaborative partnership whose success is reliant upon participation by all stakeholders. To achieve these goals, we will train and maintain additional staff in facility management, maintenance and operations, create and optimize standard operating procedures that ensure safe and secure operation of the NERBL, and develop fiscal and resource management plans that support long-term sustainability and success of research activities responsive to both investigator-initiated requests and PPP/EI NIAID specific priorities.