Enhancing SEBLAB Research Productivity, Operations and Core Laboratory Support

项目摘要 UAB东南生物防护实验室（SEBLAB）是12个区域生物防护实验室之一。 NIAID为推进BSL-3研究和大流行防范而建立的实验室（RBL）。连续 自2009年以来，NIAID奖1G 20 AI 167409 -01使非自然磨损的修复成为可能， 科学设备和空气平衡、排气、能量回收和净化的必要升级 系统.随后，NIAID奖1G 20 AI 167409-S1使收购尖端科学 设备.目前的提案概述了安全有效地转化这些投资的战略计划 提高研究生产力和创新突破性科学发现。核心-1概要 设施运行支持、人员支持和更换必要的基本科学设备 SEBLAB促进安全和高效的高遏制研究计划。Core-2旨在支持一个坚实的 有效的生物安全工作人员队伍、外部培训机会，以及制定和实施高级别的 高质量的内部培训计划对高遏制研究的安全执行至关重要。核心-3概述了 战略计划，以建立封闭内的综合核心服务， 尖端技术、优化的研究生产力和突破性的科学创新。后 完成后，该项目将实现以下目标：1）支持SEBLAB设施的运营费用; 2）资助 领导，行政和技术人员需要操作这个高度复杂的设施，3）取代现有的 基本科学设备，4）支持高质量的BSL-3生物安全培训，5）建立综合研究 6）优化和提高SEBLAB科研生产力，7）培养 RBL/NBL网络合作，以及8）资助和维持一支高技能的BSL-3科学工作队伍， 在新出现的流行病威胁的前线迅速作出反应。

Project Summary The UAB Southeastern Biocontainment Laboratory (SEBLAB) is one of 12 Regional Biocontainment Laboratories (RBL) established by NIAID to advance BSL-3 research and pandemic preparedness. In continuous operation since 2009, NIAID award 1G20AI167409-01 enabled the repair of natural wear and tear on non- scientific equipment and essential upgrades to air balance, exhaust, energy recovery, and decontamination systems. Subsequently, NIAID award 1G20AI167409-S1 enabled the acquisition of cutting edge scientific equipment. The current proposal outlines a strategic plan to safely and effectively translate these investments into increased research productivity and innovative ground-breaking scientific discoveries. Core-1 outlines facility operations support, personnel support, and replacement of essential basic scientific equipment required for SEBLAB to foster safe and productive high containment research programs. Core-2 seeks to support a solid and effective biosafety workforce, external training opportunities, and development and implementation of high quality internal training programs critical to the safe execution of high containment research. Core-3 outlines a strategic plan to establish integrated core services within containment enabling the safe and efficient use of cutting edge technologies, optimized research productivity, and ground-breaking scientific innovation/s. Upon completion, this project will achieve the following: 1) Support SEBLAB facility operational expenses; 2) Fund the leadership, administrative, and technical staff required to operate this high complexity facility, 3) Replace existing basic scientific equipment, 4) Support high quality BSL-3 biosafety training, 5) Establish integrated research cores within high containment, 6) Optimize and boost SEBLAB scientific research productivity, 7) Foster RBL/NBL network collaboration, and 8) Fund and maintain a highly skilled BSL-3 scientific workforce ready to rapidly respond at the frontline of emerging pandemic threats.