Administrative supplement to afferent neurocardiac signals, cue reactivity, and cognitive control

摘要 这是对现有的R21，NIAAA R21 AA029604的行政补充申请，标题为 传入神经心脏信号、提示反应性和认知控制。有意识地试图控制酒精 环境中的酒精暗示可能会破坏使用，这些提示会引起自动注意和生理上的 扰乱行为控制的唤醒过程。我们之前发现，一种行为形式的 神经调节，称为“共振起搏呼吸”，可以改变被动观看时大脑的激活。 酒精暗示。目前的研究测量了在主动认知处理过程中的大脑反应 酒精提示并检查这种形式的神经调节是否可以用来降低提示反应性和 实时增强认知控制。这项行政补充要求是为了支持我们的能力 将R21 AA029604中的数据统一为通用定义，包括创建新的与事件相关的 潜在的(ERP)数据结构，并将它们存放在国家酒精滥用和酒精中毒研究所 数据存档(NIAAADA)。我们有能力投入所需的时间和精力来满足这一要求 母项目将为科学界保存这一独特而宝贵的数据资源。公众 一种可获得的、简单且易于训练的神经调节技术对减少酒精暗示的健康意义 突出是很重要的，因为线索反应性和渴望是过度饮酒和复发的关键诱因。

Abstract This is an application for an Administrative Supplement to an existing R21, NIAAA R21 AA029604 titled “Afferent neurocardiac signals, cue reactivity, and cognitive control”. Conscious attempts to regulate alcohol use can be undermined by alcohol cues in the environment that elicit automatic attention and physiological arousal processes that interrupt behavioral control. We previously discovered that a behavioral form of neuromodulation, termed ‘resonance paced breathing,’ can alter brain activation during passive viewing of alcohol cues. The current study measures brain response during active cognitive processing in the context of alcohol cues and examines whether this form of neuromodulation can be used to reduce cue reactivity and enhance cognitive control in real time. This Administrative Supplement request is to support our ability to harmonize data from R21 AA029604 to a common definition, including the creation of new event-related potential (ERP) data structures, and deposit them in the National Institute on Alcohol Abuse and Alcoholism Data Archive (NIAAADA). Our ability to devote the needed time and effort to fulfill this requirement for the parent project will preserve this unique and valuable data resource for the scientific community. The public health significance of an accessible, brief, and easily trained neuromodulation technique to reduce alcohol cue salience is great, as cue reactivity and craving are key precipitants of excessive drinking and relapse.