Admin-Core-001

项目摘要 这一行政核心将发挥三项职能。作为第一个功能的一部分， 协调主要项目、合作项目和试点项目。在固定时间 每个月的第一个星期一，项目协调员和三个项目的研究者和共同研究者将在马萨诸塞州进行面对面或电话会议 总医院负责制定进度表，协调研究和样本收集。这些 会议将在目前每月定期举行的会议基础上扩大。第二个进球 这一核心将使人类免疫学研究的工具，以其他 MGH研究IgG4相关疾病以外的自身免疫性疾病的研究人员 包括下一代测序的剧目，专业知识与研究免疫细胞， 深入组织、细胞储存和分析技术。ACE计划协调员将 定期通知更广泛的MGH社区每月会议的时间和地点 主要研究者将留出一个小时与临床医生和其他 MGH的调查人员寻求互动。这些互动也将促进一些 IgG4相关疾病和系统性硬化症病因的主要项目研究。 该核心及其协调员的第三个目标是创建一个门户网站， 其他ACE，并分享有关免疫库、微生物群落 特征和染色质数据与全国各地的其他小组工作， 自身免疫，不一定限于其他ACE。

Project Summary This Administrative Core will mediate three functions. As part of the first function it will help coordinate the Principal Project, the Collaborative Project and the Pilot Project. At a fixed time on the first Monday of every month the project coordinator and the Investigators and Co-investigators of the three projects will meet face to- face or by conference call at Massachusetts General Hospital to chart progress and coordinate studies and sample collection. These meetings will expand on ongoing regular monthly meetings currently being held. A second goal of this Core will be to make available tools of Human Immunology research to other investigators at MGH studying autoimmune disorders other than lgG4-Related Disease including Next Gen sequencing for repertoire, expertise with investigating immune cells and tissues in depth, cell storage and profiling techniques. The ACE program coordinator will regularly inform the broader MGH community of the time and location of the monthly meetings and an hour will be set aside by the Principal Investigator to meet clinicians and other investigators at the MGH who seek to interact. These interactions will also facilitate some of the studies of the Principal Project on the causes of IgG4 related disease and systemic sclerosis. The third goal of this Core and its coordinator will be to generate a portal for interaction with other ACEs and to share information on Immune repertoires, microbial community characteristics and chromatin data with other groups working across the country on autoimmunity, not necessarily restricted to other ACEs.