Clinical Studies Investigating Aggressive Behaviors And

一项双盲研究在精心挑选的67名家庭暴力肇事者中比较了氟西汀和安慰剂的效果，初步结果表明，戒酒和服用氟西汀都会降低肇事者具有攻击性的可能性。在过去一年中，议定书的应计工作已经完成，我们正在进行数据分析。在这项分析中，我们将利用功能磁共振成像(FMRI)检测氟西汀对攻击性、饮酒、情绪、与配偶/重要他人互动时的情绪表达以及对情绪刺激的反应的影响。希望这项研究的结果将：1)帮助我们更好地了解酒精与攻击性之间的相互作用；2)为有家庭暴力史的酒精依赖者带来新的治疗形式。

Preliminary results from a double blind study, comparing the effects of fluoxetine with placebo in a carefully selected group of 67 perpetrators of domestic violence, show that both abstinence from alcohol and the administration of fluoxetine decrease the likelihood that perpetrators will be aggressive. During the past year accrual for the protocol has been completed and we are in the process of performing the data analysis. In this analysis we will be examining the effect of fluoxetine on aggression, alcohol consumption, mood, emotional expressions during interactions with their spouse/significant others, and response to emotional stimuli using functional MRI (fMRI). It is hoped that the results from this study will: 1) help us to better understand the interaction between alcohol and aggression, and 2) lead to new forms of treatment for alcohol dependent individuals who have a history of domestic violence.