Duke Training Grant in Digestive Diseases and Nutrition

描述（由申请人提供）：这是自1965年以来一直支持杜克GI分部研究培训的T32项目的竞争性续期申请。该计划的目标仍然是培养具有博士学位（MD，PhD或MD/PhD）的优秀个人，以进行与胃肠道，胰腺和肝脏疾病的基本机制，治疗和结局相关的独立调查。自2006年最后一次更新资金以来，该计划已毕业4 MD研究人员（2男/2女），他们现在都是杜克GI部门的正式成员。每个人都已经从NIH和/或基金会获得了进一步的研究职业发展资金。另外3名MD学员（包括一名亚裔美国妇女）将很快完成T32培训支持。所有这些也将留在杜克继续培训，三人中有两人最近获得了研究赠款，以支持他们继续职业发展。另外两名医学博士（包括一名女性）将于2010年7月进入T32项目。另外两名医学博士受训人员，包括一名非洲裔美国妇女，已被选定在2011年7月入学。在此更新期间，培训计划已被重新组织成3个轨道，以更清楚地描述我们三个卓越研究领域的培训计划和教师：基础科学（轨道I），临床研究（轨道II）和成果研究（轨道III）。它为技术，概念，原则和态度的强化培训提供了独特的机会，这将使我们的学员能够从事研究GI/肝脏疾病的基本机制，治疗和结果的职业。通过我们的计划培训的医生和博士将做好最佳准备，在转化研究中发挥关键作用，旨在：1）使用最先进的分子方法阐明疾病机制; 2）获得新的临床见解，诊断和胃肠道/肝脏疾病的自然史; 3）开发胃肠道和肝脏疾病的新治疗方法;以及4）完善临床医生实践和健康提供系统，以优化GI和肝脏疾病的新知识/治疗的积极影响。我们的计划最近的跟踪记录证明了它在实现这些里程碑方面的成功，这些里程碑是推进GI/肝脏疾病预防，治疗和治愈的先决条件。

DESCRIPTION (provided by applicant): This is the competing renewal application for a T32 program that has been supporting research training in the Duke GI Division since 1965. The goal of the program remains to train outstanding individuals with doctoral degrees (MD, PhD, or MD/PhD) to conduct independent investigation relevant to the basic mechanisms, treatment, and outcomes of gastrointestinal, pancreatic, and liver diseases. Since funding was last renewed in 2006, the program has graduated 4 MD researchers (2 men/2 women), all of whom are now full members of the Duke GI Division faculty. Each has already secured further research career development funding from NIH and/or foundations. Another 3 MD trainees (including an Asian American woman) will soon be completing T32 training support. All of these will also remain at Duke to continue training, and two of the three recently won research grants to support their continued career development. Another two MDs (including a woman) will enter the T32 program in July 2010. Two other MD trainees, including an African American woman, have been selected for enrollment in July 2011. During this renewal, the training program has been re-organized into 3 Tracks to more clearly delineate the training programs and faculty in our three areas of research excellence: basic science (Track I), clinical research (Track II) and outcomes research (Track III). It provides a unique opportunity for intensive training in techniques, concepts, principles, and attitudes which will permit our trainees to pursue a career in research into the basic mechanisms, treatments, and outcomes of GI/liver diseases. Physicians and Ph.D.s trained by our program will be optimally prepared to play key roles in translational research aimed at: 1) elucidating disease mechanisms using state of the art molecular approaches; 2) gaining new clinical insights into the diagnosis and natural history of GI/liver diseases; 3) development of new treatment approaches for GI and liver disorders; and 4) refining clinician practice and health delivery systems to optimize the positive impacts of new knowledge/treatments of GI and liver diseases. Our program's recent track record attests to its success at achieving these mile stones that are pre-requisites for advancing prevention, treatment, and cure of GI/liver diseases.