Cancer Center Support Grant (CCSG)

描述(申请人提供)：圣犹大儿童研究医院的使命是通过研究和治疗为患有灾难性疾病的儿童找到治疗方法。医院的资源在其44年的历史中一直专注于儿科癌症，癌症中心29年来一直由CCSG提供支持。通过美国黎巴嫩叙利亚联合慈善机构(ALSAC)的支持，这是一个单独的公司，其唯一目的是筹集资金支持圣裘德儿童研究医院，患者被接受时不考虑支付能力。通过ALSAC对医院的公共支持为我们的癌症中心提供了坚实的基础，在此基础上，外部资助的研究和CCSG的支持可以发挥其最大的潜力。在目前的申请中，描述了六个多学科研究计划。分子肿瘤学(MO)和信号转导(ST)计划侧重于基础的、以发现为导向的研究。实体恶性肿瘤(DTSM)、血液恶性肿瘤(HM)、神经生物学和脑肿瘤(NBT)以及癌症预防和控制(CPC)计划强调将实验室或人口科学转化为临床应用。后一项计划对于这一应用来说是新的，代表着长期致力于对患者群体的长期跟踪，最近对人口科学的承诺，以及成功招募一位世界级科学家来领导这一领域的努力。癌症中心139名成员的研究得到了12个共享资源和出色的临床研究基础设施的支持。在之前的资助期间，任命了一位新的癌症中心主任，我们癌症中心的整体结构及其领导层通过几项组织变革得到了加强，包括将支持大规模临床试验工作的基础设施纳入癌症中心的行政管理之下。在过去的资助期间，几个项目负责人的更换以及成功招聘了三个新的优秀系主任(免疫学、化学生物学和流行病学/癌症控制)，大大加强了我们癌症中心项目所做的多学科科学。圣裘德癌症中心的研究人员在资助期间发表了2000多篇与癌症有关的出版物，其中20%是方案内互动，15%是方案间互动。目前，圣裘德大学为癌症研究提供的校外资助每年超过5000万美元，其中3100万美元来自NCI/HHMI。圣犹大儿童研究医院最近经历了一个强有力的战略规划过程，并做出了坚定和长期的承诺，将继续专注于癌症研究。

DESCRIPTION (provided by applicant): The mission of St. Jude Children's Research Hospital is to find cures for children with catastrophic illnesses through research and treatment. The resources of the hospital have been focused on pediatric cancer throughout its 44 year history and the Cancer Center has been supported by a CCSG for 29 years. Through the support of the American Lebanese Syrian Associated Charities (ALSAC), a separate corporation whose only purpose is to raise money in support of St. Jude Children's Research Hospital, patients are accepted without regard to ability to pay. Public support of the hospital through ALSAC provides a strong foundation for our Cancer Center upon which extramurally funded research and CCSG support can be leveraged to their fullest potential. In the current application, six multidisciplinary research programs are described. The Molecular Oncology (MO) and Signal Transduction (ST) Programs focus on basic, discovery-oriented research. The Developmental Therapeutics for Solid Malignancies (DTSM), Hematologic Malignancies (HM), Neurobiology and Brain Tumor (NBT), and Cancer Prevention and Control (CPC) Programs emphasize the translation of laboratory or population science to clinical application. The latter program is new to this application and represents the culmination of a long-standing commitment to long-term follow-up of our patient population, a recent commitment to population sciences, and successful recruitment of a world-class scientist to lead efforts in this area. Research by the 139 members of the Cancer Center is supported by 12 Shared Resources and an outstanding clinical research infrastructure. During the previous funding period, a new Cancer Center Director was appointed and the overall structure of our Cancer Center and its leadership were enhanced by several organizational changes, including bringing the infrastructure supporting the expansive clinical trials efforts administratively under the Cancer Center's authority. Several Program leader changes and the successful recruitment of three new outstanding Department Chairs (Immunology, Chemical Biology, and Epidemiology/Cancer Control) during the last funding period significantly enhance the multidisciplinary science done by our Cancer Center Programs. St. Jude Cancer Center investigators had over 2000 cancer-related publications during the funding period, 20% of which represented intraprogrammatic interactions and 15% of which were inter-programmatic. Extramural support for cancer research done at St. Jude is currently over $50 million per year, $31 million of which is from the NCI/HHMI. St. Jude Children's Research Hospital recently went through a vigorous Strategic Planning process and made a strong and long-term commitment to remain focused on cancer research.