NW Research Center for Excellence in Biodefense and Emerging Infectious Diseases

描述（由申请人提供）：该地区X西北地区卓越中心（NWRCE）的生物防御和新兴传染病是生物医学研究计划的全国网络的重要组成部分，以打击传染病对人口的威胁。NWRCE目前是一个高度互动的主题计划，专注于革兰氏阴性细菌病原体，自成立以来一直存在相同的一般一致的重点。有三个研究主题：（1）革兰氏阴性细菌致病机制，（2）对革兰氏阴性细菌病原体的先天免疫反应，以及（3）将（1）和（2）转化为早期治疗开发以预防或治疗革兰氏阴性细菌疾病。NWRCE的中心位于西雅图的华盛顿大学（UW）;在本次更新申请中，西雅图提出了多个研究中心，俄勒冈州提出了两个研究中心，爱达荷州提出了一个研究中心，马里兰州提出了一个研究中心。其他合作地点包括蒙大拿州的NIAID落基山实验室、维多利亚大学、不列颠哥伦比亚省，以及泰国、瑞典和墨西哥的合作者。项目、核心、国内和国际网站以及合作者都是高度互动的。在上一个资助期和NWRCE成立之前，提出这一建议的个人已经共同工作了多年。大多数新加入到这一申请中的研究人员都与该中心的成员有着长期的合作关系。NWRCE的互动性质和重点是该计划的主要优势，使NWRCE能够快速灵活地响应国家优先事项，以实现革兰氏阴性细菌感染方面的重要目标。 相关性：西北地区生物防御和新发传染病卓越中心（NWRCE）是一个大型传染病研究计划，由太平洋西北部及其他地区的许多研究人员组成。该中心进行研究，以了解细菌性疾病，并对这些被认为具有国家重要性的感染制定对策。 战略管理体系描述： NWRCE的发展和管理是通过主要行政人员（主任、副主任、助理主任、实验室经理和奖项主任）以及在奖项颁发过程中增加的职位和人员的共同努力实现的。NWRCE活动的协调和中央选择代理实验室的管理是由这个小组完成的，提供了一个信息交换所以及RCE分散元素之间的沟通渠道。具体而言，行政核心组织和管理国家水资源和环境委员会的资源，组织会议，并以其他方式促进国家水资源和环境委员会所有组成部分之间的沟通，编写报告和衡量成果，确保遵守有关材料、数据和设施的生物安全和安保的条例，在解决执行国家水资源环境教育战略计划中的弱点的同时，确定国家水资源环境教育新活动和转化活动的机会，通过奖励计划招募个人并管理发展和职业发展项目，保持符合知识产权要求，保持符合爱国者法案，并建立与地方，地区和国家公共卫生网络的接口，以便NWRCE能力可以在国家或地区公共卫生紧急情况下使用。

DESCRIPTION (provided by applicant): The Region X Northwest Regional Center of Excellence (NWRCE) for Biodefense and Emerging Infectious Diseases is an essential component in a nationwide network of biomedical research programs to combat infectious disease threats to the population. The NWRCE is currently a highly interactive and thematic program focused on Gram-negative bacterial pathogens, and the same general consistent focus has existed since its inception. There are three research themes: (1) mechanisms of Gram-negative bacterial pathogenesis, (2) innate immune responses to Gram-negative bacterial pathogens, and (3) translation of (1) and (2) into early stage therapeutic development to prevent or treat Gram-negative bacterial diseases. The NWRCE is centered at the University of Washington (UW) in Seattle; in this renewal application, multiple sites are proposed in Seattle, two in Oregon, one in Idaho, and one in Maryland. Additional sites for collaboration include the NIAID Rocky Mountain Laboratory in Montana, the University of Victoria, British Columbia, and collaborators at sites in Thailand, Sweden, and Mexico. The projects, cores, domestic and international sites, as well as collaborators, are highly interactive. The individuals that make up this proposal have worked together for many years during the last funding period and before the NWRCE was created. The majority of investigators newly added to this to this application for renewed funding of the NWRCE have had long collaborative relationships with members of the center. The interactive nature and focus of the NWRCE is a major strength of the program and allows the NWRCE to rapidly and nimbly respond to national priorities to achieve important objectives with respect to Gram-negative bacterial infections. RELEVANCE: The Northwest Regional Center of Excellence for Biodefense and Emerging Infectious Diseases (NWRCE) is a large infectious disease research program composed of many investigators in the Pacific Northwest and beyond. The center conducts research to understand bacterial disease and produce countermeasures against these infections which are deemed of national importance. STRATEGIC MANAGEMENT PLAN DESCRIPTION: The development and management of the NWRCE has been achieved through the combined efforts of the key administrative staff (Director, Associate Director, Assistant Director, Laboratory Manager, and Award Director) as well as the positions and personnel which have been added during the course of the award. The coordination of NWRCE activities and the management of the central select agent lab is accomplished by this group, providing a clearinghouse for information as well as a conduit for communication among the dispersed elements of the RCE. Specifically, the Administrative Core organizes and manages the resources of the NWRCE, organizes meetings and otherwise facilitates communication between all components of the NWRCE, prepares reports and measures outcomes, ensures compliance with regulations regarding biosafety and security of materials, data, and facilities, identifies opportunities for new and translational activities of the NWRCE while addressing weaknesses in the execution of the NWRCE strategic plan, recruits individuals and administers developmental and career development projects through the Award Program, maintains compliance with intellectual property requirements, maintains compliance with the Patriot Act, and establishes an interface with the local, regional, and national public health network so that NWRCE capability can be utilized in a national or regional public health emergency.