Pulmonary Diseases in WTC Workers: Symptoms, Function, and Chest CT Correlates

项目摘要 该提案的总体目标是描述WTC相关下气道疾病的特征， 新开发的可能与不利疾病表达相关的肥胖相关成像标志物 和功能结果，并评估其与WTC职业暴露水平的相互作用。为此我们 将利用WTC肺评估单位胸部CT成像档案，一个大型数据库， 2016年2月开始运营的1700名WTC工人的3000张胸部CT图像，我们建立了 我们之前的项目。在这个子队列中，我们还将广泛的数据集与疾病症状联系起来， WTC前和WTC相关的职业暴露，详细的肺功能和纵向 肺活量测定和体重趋势，视觉成像分类和分级，以及定量 计算机辅助方法（QCAM）测量气道和肺实质异常。与 我们提议的研究项目更新，我们将继续通过定期更新丰富大多数数据来源， 为了描述WTC相关的下呼吸道疾病及其最重要的不良预后， 风险因素，并评估其纵向轨迹。

Project Summary The overall goal of this proposal is to characterize the WTC-related lower airway disorders, to investigate newly developed obesity-related imaging markers that may be associated with unfavorable disease expression and functional outcomes, and assess their interaction with WTC occupational exposure level. To that end, we will utilize the WTC Pulmonary Evaluation Unit Chest CT Imaging Archive, a large database with more than 3000 chest CT images on 1700 WTC workers that became operational in February 2016 and we established with our previous project. On that subcohort, we have also linked extensive datasets with disease symptoms, both pre-WTC and WTC-related occupational exposures, detailed pulmonary function and longitudinal spirometry measurements and weight trends, visual imaging classification and grading, and quantitative computer assisted method (QCAM) measurements of airway, and pulmonary parenchymal abnormalities. With our proposed research project renewal, we will continue to enrich most sources of data with periodic updates, in order to characterize the WTC-related lower airway diseases and their most important adverse prognostic risk factors, and evaluate their longitudinal trajectories.