Integrative Center for Neurogenetics and Neurogenomics - Overall

 描述（由申请人提供）：本申请是为了更新NINDS P30机构中心核心，NINDS神经遗传学和神经基因组学信息学中心，ICNN。ICNN成立于2009年，为加州大学洛杉矶分校大型高度互动的神经科学社区成员提供遗传学和基因组学研究。在过去的资助周期中，ICNN 1）加快了最初申请中指定的8名NINDS资助研究人员的10个项目的进展; 2）通过ARRA补充和销售和服务协议，将其范围和支持扩展到加州大学洛杉矶分校的其他神经科学家，因此它现在参与了授予加州大学洛杉矶分校神经科学家的所有NINDS R 01的三分之一，基本上所有的都包括基因组研究; 3）贡献了29篇出版物（+8提交），以及多次成功的赠款申请，包括培训奖辅导;和4）扩大其教师和分析组合，以强调计算生物学和神经遗传学领导者之间的合作，以及实施创新的数据分析方法。总之，ICNN在其最初的获奖期间为支持加州大学洛杉矶分校基因组学神经科学研究的长期自我维持实体奠定了基础，并促进了一些项目和培训赠款。随着上一个资助周期中教师队伍的扩大和坚实的计算基础设施的到位，ICNN在续约中建议继续支持NINDS赠款（9名命名用户中的15名），继续开发创新的遗传学和基因组学方法，并继续促进神经遗传学和神经基因组学在加州大学洛杉矶分校的神经科学界。

 DESCRIPTION (provided by applicant): This application is to renew an NINDS P30 Institutional Center Core, the NINDS Informatics Center for Neurogenetics and Neurogenomics, ICNN. The ICNN, founded in 2009, facilitates research in genetics and genomics for members of the large and highly interactive neuroscience community at UCLA. Over the past funding cycle, ICNN has 1) accelerated the progress of ten projects from eight NINDS-funded investigators specified in the initial application; 2) through an ARRA supplement and a sales and service agreement, extended its scope and support to additional neuroscientists at UCLA, so that is it is now involved in one third of all the NINDS R01s awarded to UCLA neuroscientists, essentially all the ones encompassing genomic studies; 3) contributed to 29 publications (+8 submitted), and multiple successful grant applications, including mentoring on training awards; and 4) expanded its faculty and analysis portfolio, to emphasize collaborations between leaders in computational biology and neurogenetics, and the implementation of innovative methods for data analysis. In summary, ICNN, in its initial award period, laid the foundation for a long-term, self- sustained entity supporting genomics neuroscience research at UCLA and has facilitated a number of projects and training grants. With an expanded faculty and a solid computational infrastructure put in place in the previous funding cycle, ICNN proposes in the renewal to continue to support NINDS grants (15 from 9 named users), to continue to develop innovative genetics and genomics approaches, and to continue to foster neurogenetics and neurogenomics for the neuroscience community at UCLA.