Integrative Systems Core

ISC项目摘要 综合系统核心(ISC)的目标是提供综合的、多学科的知识、技能 以及促进对生物力学、结构、功能、生理和 生物学对年龄相关的活动和平衡的影响。匹兹堡大学有许多高度 受人尊敬的教职员工，他们专门研究与老年人的平衡和流动性有关的学科 运营支持我们目标的最先进的实验室。ISC核心的领导人提供咨询， 为大学的老龄化研究工作提供建议和使用这些成熟的设施。在 在上一个周期，这一核心具有很高的生产力，支持了22项试验性研究、9个发展项目和 39项外部赠款。支持导致了16项新赠款的资助，其中2项是由患者中心资助的 结果研究所(PCORI)。在ISC的支持下，已出版了128多份OAIC出版物。 综合系统核心的具体目标是： 1.通过使用涵盖神经成像、生物力学、 生理学和生物学。 2.就现有基础设施向调查人员提供咨询，并便利实验室的使用。 3.协调核心内部资源的利用并确定其优先次序。 4.为调查人员开发新技术和综合、免费的方法。 5.支持胡椒中心研训任务。 6.与机构内外的其他核心和单位就与伊斯兰会议组织主题有关的问题开展合作 活动。 在第一个和第二个奖项周期中赞助的许多设施仍然是这一核心的一部分。 包括人体运动分析、神经成像、生物力学和感觉统合评估 能力。在这次更新中，我们正在扩大我们的范围，以包括两个领域的额外实验室设施 支持关于活动、平衡和衰老的协作性综合研究：1)运动生理学，2) 生物学。我们有新的技术来对运动中稳定状态的大脑进行成像，创新的设备可以 监测步态，以及检查肌肉功能的技术。 除了提供咨询和使用设施外，ISC还将支持3个试点提案 (PESC 1，2，4)，11个外部项目，以及一个旨在重现现实生活的发展项目 实验室中的环境挑战，并检查在导航期间的认知和功能状态 改变了环境。

ISC Project Summary The goal of the Integrative Systems Core (ISC) is to provide integrative, multidisciplinary knowledge, skills and techniques that foster an understanding of the biomechanical, structural, functional, physiological and biological influences on age-related mobility and balance. The University of Pittsburgh has numerous highly regarded faculty members who specialize in disciplines linked to balance and mobility in older adults and operate state-of-the-art laboratories that support our goals. The leaders of the ISC Core provide consultation, advice and access to these well-established facilities for aging research efforts across the University. In the previous cycle this core was highly productive and supported 22 pilot studies, 9 developmental projects, and 39 external grants. Support led to funding of 16 new grants of which, 2 are funded by Patient Centered Outcome Research Institute (PCORI). The ISC support has resulted in over 128 OAIC publications. The Specific Aims of the Integrative Systems Core are to: 1. Provide expertise through use of an integrative systems approach spanning neuroimaging, biomechanics, physiology and biology. 2. Provide consultation to investigators about existing infrastructures and facilitate the use of laboratories. 3. Coordinate and prioritize the utilization of resources within the Core. 4. Develop new technologies and integrative, complimentary approaches for investigators. 5. Support the research training mission of the Pepper Center. 6. Collaborate with other cores and units within and outside the institution on OAIC theme-related activities. Many of the facilities sponsored in the first and second cycles of the award continue to be part of this core and include human movement analysis, neuroimaging, biomechanics, and assessment of sensory integration capabilities. In this renewal we are broadening our scope to include additional laboratory facilities in 2 areas supportive of collaborative integrative research on mobility, balance and aging: 1) exercise physiology, and 2) biology. We have new techniques for imaging the brain at steady state during motion, innovative devices to monitor gait, and techniques to examine muscle function. In addition to providing consultation and access to the facilities, the ISC will support 3 pilot proposals (PESC 1,2,4), 11 external projects, and a developmental project with the goal to recreate real life environmental challenges in the lab and examine cognitive and functional status during navigation of the altered environment.