Mentoring patient-oriented research on the health consequences of polydrug use

 描述（由申请人提供）：Elise Riley博士是加州大学旧金山弗朗西斯科医学系的副教授。作为一名流行病学家，她共同指导了17名初级研究人员，并制定了一项长期的多学科研究计划，重点是艾滋病毒，药物使用，健康状况和极低收入人群的卫生服务使用。她目前由NIDA资助进行一项关于艾滋病毒和多种药物使用对心脏损伤影响的无家可归妇女健康研究。在这里，她提出了一个扩展的母研究，包括两个新的生物标志物的结果，这将提供一个更好的理解心功能障碍，通过考虑多种生理途径。在这个扩大的研究机构内，Riley博士进一步建议同时增加她对早期职业临床医生和学员的指导活动。拟议的活动利用现有的基础设施，数据和合作提供的博士莱利的当前计划，以及额外的NIH和UCSF资源。总的来说，他们将提供多种职业发展机会，为面向患者的研究人员提供强有力的指导计划，并开展新项目，重点了解同时发生的暴露和健康状况，以更好地为高度脆弱人群提供医疗保健服务。

 DESCRIPTION (provided by applicant): Dr. Elise Riley is an Associate Professor in the Department of Medicine at the University of California, San Francisco. Trained as an epidemiologist, she has co-mentored 17 junior investigators and developed a longstanding multidisciplinary research program focused on HIV, drug use, health status and the use of health services in very low-income populations. She is currently funded by NIDA to conduct a homeless women's health study regarding the influences of HIV and polydrug use on cardiac injury. Here she proposes an expansion of the parent study to include two new biomarker outcomes, which will provide a better understanding of cardiac dysfunction through the consideration of multiple physiological pathways. Within this expanded body of research, Dr. Riley further proposes the concurrent augmentation of her mentoring activities for early career clinicians and trainees. The proposed activities leverage existing infrastructure, data and collaborations provided by Dr. Riley's current program, as well as additional NIH and UCSF resources. Collectively they will provide multiple opportunities for career development, a strong mentoring program for patient-oriented researchers and new projects that focus on understanding co-occurring exposures and health conditions to better inform health care delivery in highly vulnerable populations.