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Pregnancy Malaria Vaccine development

Pregnancy Malaria Vaccine development
妊娠期疟疾疫苗开发
批准号：
9566748
负责人：
Patrick Duffy
金额：
$30.39万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/9566748
关键词：
AnemiaAnimalsAntibodiesAntigensBindingChondroitin Sulfate AGoalsImmunityImmunizeInfant MortalityLow Birth Weight InfantMalariaMalaria VaccinesMediatingModelingMolecularParasitesPathogenesisPlacentaPre-EclampsiaPregnancyPregnancy lossProteinsPublic HealthTestingWomanexperimental studyinhibiting antibodynonhuman primatereceptor bindingvaccine development

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中文摘要
翻译
妊娠期疟疾是一个重大的公共卫生问题，与严重的孕产妇贫血、子痫前期、妊娠流产、低出生体重分娩和婴儿死亡率有关。PM是由结合硫酸软骨素A受体（CSA）的寄生虫在胎盘中的隔离引起的。先前的离体实验表明，获得对CSA结合寄生虫的特异性免疫的多孕妇女的抗体，或免疫了介导寄生虫与CSA结合的抗原的动物的抗体，可以抑制寄生虫与CSA的结合。
英文摘要
Pregnancy malaria (PM) is a major public health problem associated with severe maternal anemia, preeclampsia, pregnancy loss, low birthweight delivery and infant mortality. PM is caused by sequestration in the placenta of parasites that bind the receptor chondroitin sulfate A (CSA). Previous ex vivo experiments have shown that parasite binding to CSA can be inhibited by antibodies from multigravida women who acquired specific immunity to CSA-binding parasites, or by antibodies from animals immunized with antigens that mediate parasite binding to CSA.
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会议论文
Malaria Surveillance and Research Studies in Liberia and Guinea-Conakry
Malaria Transmission Blocking Vaccine Discovery
Malaria Pathogenesis in young children and vaccine discovery
Malaria Vaccine: Pfs25-rEPA
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