Applied Physiology and Tissue Mechanisms

7.项目摘要-资源核心2 心血管失调，慢性炎症和内分泌代谢功能障碍是固有的， 老年人因慢性衰老疾病致残而造成的身体损伤的病理生理学。 肌肉减少症、体能差、炎症和导致残疾的急性事件--如福尔斯、中风和髋关节 骨折--随着年龄的增长而发生，可能会使活动能力恶化，增加患心血管疾病的风险 (CVD)和代谢异常应用生理学和组织机制资源核心（RC-2） 假设是，运动和基于活动的康复可以改善多个生理系统， 老年人，行动不便的人，导致改善功能表现，减少心脏代谢 疾病风险和预防功能衰退。这一核心集中于以下具体目标：1） 促进进行肌肉骨骼和组织机械运动康复和预防 UM-OAIC试点项目中的老龄化和残疾生物医学研究，UM-OAIC学者的研究， 发展项目（DP），以及外部NIH和VA资助的研究; 2）提供研究支持， 指导，并培训UM-OAIC学者，初级教师，和UM-OAIC研究人员在性能 与基于运动和康复的功能恢复和预防衰老相关的研究 患有慢性致残性疾病的老年人的功能下降。 RC-2领导层和研究人员代表了一个由基础科学家组成的多学科团队， 有15-20年合作经验的老年医学专家。临床和代谢的表征 RC-2中中风、髋部骨折和其他慢性致残性疾病个体的表型允许 UM-OAIC研究人员开发成功的特定运动康复策略，以改善功能 临床结果。因此，该核心与其他UM-OAIC核心合作，将继续支持 创新的研究研究，检查多系统康复的机制和生理效应 老年慢性病患者功能和生理结果的预防策略 残疾，并在新的临床试验中翻译这些结果。

7. Project Summary- Resource Core 2 Cardiovascular deconditioning, chronic inflammation, and endocrine-metabolic dysfunction are inherent to the pathophysiology of the physical impairments in older persons hindered by disabling chronic diseases of aging. Sarcopenia, poor fitness, inflammation, and acute events causing disability -- such as falls, stroke, and hip fracture -- occur with advancing age and may worsen mobility and increase risk for cardiovascular disease (CVD) and metabolic abnormalities. The Applied Physiology and Tissue Mechanisms Resource Core’s (RC-2) hypothesis is that exercise and activity-based rehabilitation can improve multiple physiological systems in older, mobility-limited individuals, leading to improved functional performance, reduced cardiometabolic disease risk, and prevention of functional decline. This core focuses on the following specific aims: 1)To facilitate the conduct of musculoskeletal and tissue mechanistic exercise rehabilitation and preventive biomedical research in aging and disability across the UM-OAIC pilot projects, UM-OAIC scholars’ research, Development Projects (DPs), and external NIH and VA funded research; and 2)To provide research support, mentoring, and training to UM-OAIC scholars, junior faculty, and UM-OAIC researchers in the performance of aging research relevant to exercise and rehabilitation-based restoration of function and the prevention of functional declines in older people with chronic disabling diseases. RC-2 leadership and investigators represent a multidisciplinary team of basic scientists with clinical geriatricians who have worked together for 15-20 years. The characterization of the clinical and metabolic phenotype(s) of individuals with stroke, hip fracture, and other chronic disabling diseases in RC-2 have allowed UM-OAIC investigators to develop successful specific exercise rehabilitation strategies to improve functional and clinical outcomes. Thus this core, in collaboration with the other UM-OAIC cores, will continue to support innovative research studies examining the mechanisms and physiological effects of multisystem rehabilitation and preventive strategies on functional and physiological outcomes in older adults aging with chronic disabilities, with translation of these outcomes in novel clinical trials.