Emory Integrated Proteomics Core

Emory整合蛋白质组学共享资源 项目总结/摘要 埃默里综合蛋白质组学共享资源（Proteomics SR）的使命是提供蛋白质 使用尖端质谱（MS）的分析服务，以支持Winship癌症研究所。主要 蛋白质组学SR的技术平台是液相色谱-串联质谱（LC- MS/MS）用于高灵敏度鉴定和定量蛋白质及其翻译后修饰 （PTM）。蛋白质组学SR是Winship研究人员的关键技术资源， 一系列与癌细胞生物学、遗传学、表观遗传学和新疗法有关的癌症项目。主 蛋白质组学SR的目的是提供：（1）获得最先进的质谱， 和有针对性的蛋白质组学应用，（2）提供咨询，专家培训，并支持蛋白质组学相关 研究项目，（3）提供基础设施和资源，促进多学科合作 Winship调查员的研究和创新。总的来说，这些目标将导致 通过实验设计优化，为Winship研究人员提供高质量的蛋白质组学数据， 正确的解释。所提供的质谱技术对Winship研究人员至关重要， 这些蛋白质组学研究的发现是Winship努力改善预防，检测， 和治疗人类癌症。

EMORY INTEGRATED PROTEOMICS SHARED RESOURCE PROJECT SUMMARY / ABSTRACT The mission of the Emory Integrated Proteomics Shared Resources (Proteomics SR) is to provide protein analytical services using cutting-edge mass spectrometry (MS) in support of Winship Cancer Institute. The main technology platform of Proteomics SR is liquid chromatography coupled with tandem mass spectrometry (LC- MS/MS) for highly sensitive identification and quantification of proteins and their post-translational modifications (PTMs). Proteomics SR is a critical technological resource for Winship investigators and has supported a broad range of cancer projects related to cancer cell biology, genetics, epigenetics, and novel therapeutics. The primary aims of the of Proteomics SR are to provide: (1) access to state-of-the-art mass spectrometry for both discovery and targeted proteomic applications, (2) provide consultation, expert training, and support for proteomics-related research projects, and (3) provide infrastructure and resources that advance collaborative multidisciplinary research and innovation among Winship investigators. Collectively, these aims will lead to an increase in the quality of proteomics data available to Winship investigators through experimental design optimization and proper interpretation. The mass spectrometry technologies provided are vital to Winship researchers and key findings from these proteomic studies are fundamental to Winship's efforts to improve the prevention, detection, and treatment of human cancers.