Non-Invasive Venous Waveform Analysis (NIVA) in patients with Heart Failure (HF)

容量超负荷(充血)发生在心力衰竭(HF)患者中，是主要原因 世界各地老年人住院人数的增加。不幸的是，临床症状和体征； 实验室价值；现有诊断工具在提供准确评估方面不可靠 卷状态。利用独特的生理信号，无创静脉波形分析 (Niva)，VoluMetrix开发了一种专有设备(VasaWatch)，并设计了算法 用于监测心力衰竭患者的容量状态。人体和实验中的概念验证数据 动物模型表明，VasaWatch提供了血管内的可靠指示 卷状态。这项快速跟踪SBIR中的研究将确定VasaWatch是一款安全、 无创监测心力衰竭患者容量状态的灵敏、廉价的方法。

Volume overload (congestion) occurs in patients with heart failure (HF) and is the leading cause of hospitalization in the elderly worldwide. Unfortunately, clinical signs and symptoms; laboratory values; and existing diagnostic tools are unreliable in providing accurate assessment of volume status. Using a unique physiologic signal, Non-Invasive Venous waveform Analysis (NIVA), VoluMetrix has developed a proprietary device (“VasaWatch”) and algorithm designed for monitoring volume status in HF patients. Proof of concept data in humans and experimental animal models, demonstrate that VasaWatch provides a reliable indication of intravascular volume status. The studies in this Fast Track SBIR will establish that VasaWatch is a safe, sensitive, inexpensive method for non-invasive volume status monitoring in patients with HF.