Data Analysis Core

项目摘要 VU-BIOMIC数据分析核心（DAC）的任务是预分析和分析挑战。的 DAC的研究人员具有广泛的高维成像质量工作经验 光谱数据集，甚至在新的方法来处理这些数据的领域领先。此外，DAC 该团队开创了将高空间分辨率显微镜和三维数据集与联合收割机相结合的方法， IMS。然而，BIOMIC将要求DAC架构师构建一个平台，将所有预分析和 将分析计算方法转化为能够处理数据的完整计算平台 由特性化管道高效生成。所有工作的主要推动力是 重建和后续分析的自动化。这将允许对新的 数据集生成时。由于实验工作流程是广泛的，重要的是DAC 提供指标的快速反馈，以跟踪数据质量，并提供导致生物学洞察的分析。

Project Summary The VU-BIOMIC Data Analysis Core (DAC) is tasked with both pre-analytical and analytical challenges. The investigators of the DAC have broad range of experience working with high-dimensional imaging mass spectrometry data sets, even leading the field in new methodologies to process such data. In addition, the DAC team has pioneered methods to combine high spatial resolution microscopy and 3-dimensional data sets with IMS. However, BIOMIC will require that the DAC architect a platform that integrate all of the pre-analytical and analytical computational approaches into a complete computational platform capable of processing the data generated by the Characterization pipeline efficiently. A primary driving force behind all work carried out will be automation of the reconstruction and subsequent analysis. This will allow plug-and-play analysis of new datasets as they are generated. As the experimental workflow is expansive, it is important that the DAC provide rapid feedback of metrics to track data quality and provide analyses that lead to biological insight.