Administration Core

虽然基因本身并不是理解种族和民族健康的充分的单一基础 差异，差异环境的潜力--包括治疗--与差异相互作用 不同亚群中的基因互补确实构成了研究健康差异的有利背景。 在斯坦福，我们在三个关键的学术要素方面拥有突出的优势，这是形成 协调、可持续和影响深远的研究，以实践协作解决种族和民族问题 这方面的健康差异：1)在遗传标记实验室评估方面有丰富的经验 以及它们与疾病风险和治疗相关性的关系，2)社会差异研究人员， 横跨流行病学、进化生物学、卫生服务研究和经济学，以及3)新颖和 卓越的分析和高性能计算能力，最近整合到我们的部门 生物医学数据科学。在我们新的斯坦福人口健康科学中心的赞助下，我们 最近加倍了我们在社区影响方面的投资。正是在这种情况下，我们提出了 以下是该U54应用程序的总体目标： 具体目标1：将三个主要科学领域纳入新的工作关系，以实现 三个拟议研究项目中的每一个项目的目标都演变成一个综合的和可持续的 能够承担由我们的财团合作伙伴和姐妹中心提出的新颖试点项目的科学团队 在全国范围内，同时扩大我们自己的专注于健康的精准健康研究组合 随着时间的推移而产生的差异。 具体目标2：利用联合体和执行核心，发展和扩大与 我们最初的研究合作伙伴，以促进社区中关键的双向研究关系，从 随着三个拟议项目的实施并逐渐成熟为广泛的、可持续的伙伴关系，以确保 随着研究的进行，纳入了进一步受到不利影响的人群。 具体目标3：培养在不同领域内“翻译”遗传和生物信息的广泛经验 种族和族裔人口优化这种精准保健方法的应用，以减少种族 和种族差异，在这些方法是最相关的。

While genes per se are not an adequate singular foundation for understanding racial and ethnic health disparities, the potential of differential environments—including treatments—interacting with a differential complement of genes in different subgroups does constitute a fertile context for the study of health disparities. At Stanford, we have in place outstanding strengths in the three critical academic elements requisite to form a coordinated, sustainable, and far-reaching research to practice collaboration to address racial and ethnic health disparities with this focus: 1) Extensive experience both with laboratory assessment of genetic markers and their relationships to both disease risk and treatment relevance, 2) Social disparities researchers, spanning epidemiology, evolutionary biology, health services research and economics, and 3) Novel and outstanding analytic and high-performance computing capabilities, recently consolidated in our Department of Biomedical Data Science. Under the auspices of our new Stanford Center for Population Health Sciences, we have recently redoubled our investments in Community Impact. It is in this context that we propose the following overarching aims for this U54 application: Specific Aim 1: Draw together the three principal scientific domains into new working relationships to achieve the aims of each of the three proposed research projects while evolving into an integrated and sustainable science “team” able to take on novel pilot projects proposed by our consortium partners, and sister Centers around the country, while expanding our own portfolio of precision health research focusing on health disparities over time. Specific Aim 2: Availing the Consortium and Implementation Cores, develop and expand relationships with our initial research partners to facilitate critical bidirectional research relationships in the community, starting with the three proposed projects and maturing into a broad, sustainable nexus of partnerships to ensure inclusion of further adversely impacted populations as research goes forward. Specific Aim 3: Develop broad experience with “translation” of genetic and biologic information within different racial and ethnic populations to optimize the application of such precision health approaches to reduce ethnic and racial disparities where such approaches are most relevant.