Developing Diverse Physician-Investigator Leaders for the Future of Child Health

摘要 早期儿科教员，即使是那些有潜力成为学术研究人员的人 基于在基础研究方面的丰富经验，将需要在基础研究方面进一步强化培训和指导 研究成功地走上了独立的研究生涯。我们建议的儿童健康研究 职业发展奖(CHRCDA)项目名为“培养多样化的医生-研究人员领导者” 为儿童健康的未来“将提供一个前沿的研究机会，结合仔细 构建了指导和职业发展途径，使我们的学者能够成为 儿科学术研究人员的队伍。大学的基础生物医学研究培训社区 加州大学圣地亚哥分校(UCSD)有着久负盛名的卓越声誉，加州大学圣地亚哥分校的儿科现在排名 在美国国立卫生研究院所有儿科研究经费中排名前五。值得注意的是，过去5-10年 见证了加州大学圣迭戈分校儿科和 它进行的研究，再加上它与圣地亚哥拉迪儿童医院的正式合作伙伴关系， 加州最大的儿童医院。我们CHRCDA的主要目标如下：(1)增加 从事应用于儿童健康的基础研究的儿科医生-科学家的人数；(2)吸引 UCSD优秀年轻儿科医生，在世界的指导下促进他们的职业发展 (3)培养妇女和少数民族的早期职业生涯 儿童健康方面的研究人员。在我司项目先行者的密切投入下，CHRCDA 学者将全面参与加州大学圣迭戈分校国家学术医学领导中心的计划 (NCLAM)，是加州大学健康科学学院的一个长期且非常成功的初级教师指导计划， 在学术成功发展所需的所有方面提供研讨会和纵向指导 医学和多样性丰富模块，包括边境健康和一天一次的医生方案。全 CHRCDA项目的教员导师是备受推崇的科学研究人员，每个人都领导着一个充满活力和 与儿科医学密切相关的尖端基础或基础/翻译研究计划。研究 CHRCDA学者的培训机会分为六个研究主题，每个主题五名成员，其中 在计划结构、课程和指导方法中发挥不可或缺的作用：(1)基因组学、大数据和 系统生物学；(2)感染、免疫与炎症；(3)器官生理学与新陈代谢；(4)神经科学 与脑发育；(5)人类微生物组与儿童健康；(6)发育与干细胞生物学。一个 CHRCDA的指导思想将是支持尽可能多的年轻内科医生-科学家 在该计划内，在K12的三年基础上又增加了一年由部门资助的支持 支持创建一个充满活力的计划，每年有一名新学者和四名稳定状态的研究员。

ABSTRACT Early stage pediatric faculty members, even those who have potential for success as academic investigators based upon substantial experience in basic research, will require further intensive training and mentoring in basic research to successfully embark upon an independent research career. Our proposed Child Health Research Career Development Award (CHRCDA) Program entitled “Developing Diverse Physician-Investigator Leaders for the Future of Child Health” will provide a cutting-edge research opportunities, combined with a carefully constructed mentoring and career development pathway, to enable our Scholars to emerge as leaders among the ranks of pediatric academic investigators. The basic biomedical research training community at the University of California San Diego (UCSD) has a long-established reputation of excellence, and UCSD Pediatrics now ranks in the top five in NIH research funding of all Pediatric Departments in the country. Notably, the last 5-10 years have witnessed an impressive academic expansion within of the UCSD Department of Pediatrics and the research it conducts, coupled with the formalization of its partnership with Rady Children's Hospital San Diego, the largest Children's Hospital in California. The key objectives of our CHRCDA are as follows: (1) To increase the number Pediatrician-Scientists engaged in basic research as applied to children's health; (2) to attract outstanding young pediatricians to UCSD and to facilitate their career development under the guidance of world class, established investigator-faculty mentors; and (3) to cultivate the early careers of women and minority investigators in children's health. With close input from the program pioneers in our Department, CHRCDA Scholars will participate fully in the program of UCSD National Center for Leadership in Academic Medicine (NCLAM), a longstanding and highly successful junior faculty mentoring program in UC Health Sciences that provides workshops and longitudinal mentoring in all facets required for successful advancement in academic medicine, and diversity enrichment modules including the Border Health and Doc-for-A-Day programs. All CHRCDA program faculty mentors are highly regarded scientific investigators, each leading a vibrant and cutting-edge basic or basic/translational research program of strong relevance to pediatric medicine. Research training opportunities for CHRCDA Scholars are organized into six research themes of five members each, which an integral role in the program structure, curriculum and mentorship approach: (1) Genomics, Big Data & Systems Biology; (2) Infection, Immunity & Inflammation; (3) Organ Physiology & Metabolism; (4) Neuroscience & Brain Development; (5) Human Microbiome & Child Health; and (6) Developmental & Stem Cell Biology. A guiding philosophy of this CHRCDA will be to support the greatest possible number of young physician-scientists within this Program, and an additional year of Department-funded support has been added to three years of K12 support to create a vibrant program with one new Scholar per year and four fellows total in the steady state.