PDX Core

PDX核心项目总结 PDTC PDX核心的目标是建立和维持PDX系，以进行动物试验。 使用实验性和标准护理疗法的临床前试验;促进质量控制，再现性， 通过为PDX开发和维护共享的标准操作程序（SOP）， 开发、维护、实验和病原体检测;提供管理大型PDX的基础设施 收集并生成、存储和管理项目生成的基于PDX的实验数据; 促进PDXNet程序之间PDX模型的交换;并促进实验数据的传输 PDTC生物信息学核心和PDTC PDXNet数据共享和协调中心， 治疗反应取决于个体患者肿瘤的分子特征。我们的PDTC PDX核心电流 包括262条乳房PDX线，可用于我们PDTC中心内和整个PDXNet计划的项目。

PDX CORE PROJECT SUMMARY The goals of the PDTC PDX Core are to establish and maintain PDX lines for the purpose of conducting animal preclinical trials using experimental and standard-of-care therapeutics; to promote quality control, reproducibility, and collaboration by developing and maintaining shared Standard Operating Procedures (SOPs) for PDX development, maintenance, experimentation, and pathogen testing; to provide infrastructure to manage large PDX collections and to generate, store, and manage PDX-based experimental data generated by the projects; to facilitate exchange of PDX models between the PDXNet program; and to facilitate transfer of experimental data to the PDTC Bioinformatics Core and the PDTC PDXNet Data Commons and Coordinating Center to relate treatment responses to the molecular characteristics of individual patients’ tumors. Our PDTC PDX Core current comprises 262 breast PDX lines available for projects within our PDTC Center and across the PDXNet program.