Non-coding RNAs as Prognostic and Diagnostic Markers in Prostate Cancer

在本项目中，我们一直在探索两个microRNAs，miR-484和mir-769的功能。在我们以前的研究中，我们发现mir-484与前列腺外扩散有关，进一步的分析表明miR-484与降低无复发生存率显著相关。其他实验表明，miR-484的表达增加了前列腺癌细胞的迁移。人们对这种微小RNA的功能知之甚少。它是线粒体生物发生的调节器。对TargetScan预测的靶基因的通路分析表明，该microRNA可能调节新陈代谢。对这些预测函数进行了研究。此外，我们还研究了mir-769的功能及其在人前列腺癌细胞迁移和侵袭中的作用。对这两个微小RNA的研究已经完成，该项目于2019年停止。已经提交了描述miR-484功能的手稿。

In this project, we have been exploring the function of two microRNAs, miR-484 and mir-769. In our previous studies, we identified mir-484 as being associated with extraprostatic extension and further analyses revealed that miR-484 significantly associates with reduced recurrence-free survival. Additional experiments showed that miR-484 expression increases migration of prostate cancer cells. There is not much known about the function of this microRNA. It is a regulator of mitochondrial biogenesis. A pathway analysis of TargetScan-predicted target genes indicated that this microRNA may regulate metabolism. These predicted functions were investigated. Furthermore, we studied the function of mir-769 and its involvement in migration and invasion of human prostate cancer cells. Studies of these two microRNAs have been completed and the project was discontinued in 2019. A manuscript describing the function of miR-484 has been submitted.