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Chronic graft-versus-host disease

Chronic graft-versus-host disease
慢性移植物抗宿主病
批准号：
10014723
负责人：
Edward Cowen
金额：
$132.61万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10014723
关键词：
CalcinosisCase SeriesClinicalClinical TrialsCutaneousFunctional disorderImatinibInstitutesOutputPublicationsResearch PersonnelRisk FactorsRoleSkinSkin ManifestationsSpecialistSpecimenUnited States National Institutes of HealthWhole-Body Irradiationchronic graft versus host diseasemultidisciplinarynovelskin disorder

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中文摘要
翻译
这一努力仍然非常富有成效，与GVHD相关的年度出版物产量证明了这一点，包括该分支发起的伊马替尼临床试验的出版物。此外，我还对cGVHD的新皮肤表现的鉴定做出了几项重要贡献，并确定了全身照射是cGVHD的危险因素。目前的项目包括皮肤GVHD标本的ssRNA分析，以更好地了解皮肤病的病理生理。临床项目包括ruxolitinib对皮肤GVHD的首次局部研究和皮肤GVHD的皮肤钙化症病例系列。
英文摘要
This effort continues to be very productive as evidenced by the yearly publication output related to GVHD, including publication of the Branch initiated imatinib clinical trial. In addition, I have made several important contributions to the identification of novel skin manifestations of cGVHD, as well as identified the role of total body irradiation as a risk factor for cGVHD. Current projects including ssRNA analysis of cutaneous GVHD specimens to better understand the pathophysiology of skin disease. Clinical projects including the first topical study of ruxolitinib for skin GVHD and a case series on cutaneous calcinosis in skin GVHD.
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