Institute for Integration of Medicine & Science: A Partnership to Improve Health

项目摘要-摘要 德克萨斯州中南部是圣安东尼奥和奥斯汀的所在地，这两个城市都是全国 发展最快的城市。圣安东尼奥，南得克萨斯州的门户，是第七大城市，也是最大的少数民族- 美国以西班牙裔/拉丁裔为主的城市，而奥斯汀是第11大城市。该地区还包括许多农村地区 美国和墨西哥边境的几个县和几个县。鉴于我们的人口结构和快速增长，我们的地区预示着 美国医疗保健面临的未来挑战，突显了我们的中心设计的解决方案在全国范围内的适用性。 2006年，德克萨斯大学圣安东尼奥分校健康科学中心成立了医学与医学整合研究所 科学(IIMs)作为翻译研究倡议的学术发源地，培训翻译科学 劳动力，正式确定关键的战略合作伙伴关系，并在一次学习中创建学者社区 医疗保健系统。在我们优化的临床和翻译研究基础设施的基础上，IIMS现在 根据PAR-21-293建议第四周期的CTSA支持。我们的中心寻求在解决问题方面出类拔萃 临床和转化科学(CTS)的障碍，将发现转化为缩小差距和改进 我们多元文化人口的医疗保健成果。我们努力使我们的愿景成为现实，通过稳健 跨机构合作伙伴和协作组织支持CTS的战略，促进成功 针对跨学科研究团队，并实施计划，以产生创造性、协作性和 不同文化背景的翻译科学工作者。我们将通过以下战略部署实现目标 在CTSA供资的3个周期中开发的资源和专门知识。我们的方案充分利用了优化的优势 在临床和转化性研究领域建立所需的能力和基础设施 高影响力的CTS计划。因此，信息管理系统将从研究特定目标/疾病(即临床)开始。 翻译研究)到发现适用于许多目标/疾病的可概括原则(CTS)， 解决限速步骤，将经验过程转化为预测性科学。 这一指导原则嵌入到本提案的每个要素和模块中，并贯穿于我们的渠道 培训和劳动力发展计划。我们假设集线器合作伙伴之间的协同效应将产生CTS 创新，并为国家CTSA联盟做出有意义的贡献。我们总体的具体目标是： 1.在充满活力的学术之家加速CTS发现和健康差距影响 与我们的战略合作伙伴协同整合，并积极参与我们不同的社区 2.利用我们非凡的拉美裔和军人/退伍军人人口基础，实现多样化和增强 我们的跨学科临床和转化科学团队 3.实施创新战略，以评估和持续改进所有管理信息系统方案 4.从战略上注重传播和实施循证CTS进展情况 在区域和全国CTSA联盟范围内推进卫生公平的潜力

Project Summary-Abstract South-Central Texas is home to San Antonio and Austin, both among the nation’s fastest growing cities. San Antonio, the gateway to South Texas, is the 7th largest city and the largest minority- majority Hispanic/Latino city in the US, whereas Austin is 11th largest. The region also includes many rural counties and several on the US-Mexico border. Given our demographics and rapid growth, our area foreshadows future challenges facing US healthcare, underscoring the national applicability of solutions devised by our hub. In 2006, UT Health Science Center San Antonio established the Institute for Integration of Medicine & Science (IIMS) as the academic home for translational research initiatives, training the translational science workforce, formalizing key strategic partnerships, and creating a community of scholars within a learning healthcare system. Building upon our optimized clinical and translational research infrastructure, IIMS now proposes a 4th cycle of CTSA support in response to PAR-21-293. Our hub seeks to be exceptional in solving clinical and translational science (CTS) roadblocks, translating discoveries into reduced disparities and improved healthcare outcomes across our multi-cultural population. We strive to make our vision a reality through robust strategies for supporting CTS across institutional partners and collaborating organizations, catalyzing successes for transdisciplinary research teams, and implementing programs that produce a creative, collaborative, and culturally diverse translational science workforce. We will achieve our goals through the strategic deployment of resources and expertise developed during 3 cycles of CTSA funding. Our proposal leverages optimized strengths across the spectrum of clinical and translational research to establish the capacity and infrastructure required for high-impact CTS programs. Thus, IIMS will pivot from the study of specific targets/diseases (i.e., clinical translational research) to the discovery of generalizable principles that apply to many targets/diseases (CTS), addressing rate-limiting steps and transforming translation from an empirical process into a predictive science. This guiding tenet is embedded within each Element and Module of this proposal, as well as across our pipeline of training and workforce development programs. We posit that synergies across hub partners will yield CTS innovations and contribute meaningfully to the National CTSA Consortium. Our over-arching Specific Aims are: 1. Catalyze the acceleration of CTS discovery and health disparities impact within a vibrant academic home synergistically integrated with our strategic partners and actively engaged with our diverse communities 2. Capitalize on our extraordinary Hispanic and military/veteran population base to diversify and enhance our interdisciplinary clinical and translational science workforce 3. Implement innovative strategies for evaluation and continuous improvement across all IIMS programs 4. Focus strategically on dissemination and implementation of evidence-based CTS advances with high potential for advancing health equity, both regionally and across the National CTSA Consortium