CAREER-ENHANCEMENT

项目总结(职业提升核心) 罕见病临床研究网络(RDCRN)的一个关键目标是培养下一代 罕见疾病临床/翻译研究人员。脆性骨骼疾病联盟(BBDC)已经做出了 在为这项任务作出贡献方面取得了重大进展。在过去的五年里，BBDC为盖斯曼提供了 向7名高素质的早期调查人员提供研究奖学金(总共14名研究人员，由 OIF)。此外，通过利用机构资源，BBDC调查人员指导了另外10个 与OI直接相关的研究项目中的年轻研究人员。此外，20名学员还获得了旅游奖励。 出席OIF的年度科学会议和RDCRN的REARE临床研究会议 在这些疾病中，他们有机会展示他们的科学工作。BBDC增强活动还 确保受训人员积极参与OIF(主要患者权益倡导组织)的工作，并 与受OI影响的个人和家庭互动。这些策略的成功最好的例证是 在BBDC的支持下，学员在短时间内出版了80多份出版物 恰逢BBDC的1-5年。除了这些促进职业发展的活动外，BBDC还在 与OIF和美国骨与矿物协会等专业组织建立伙伴关系 美国国家骨质疏松症基金会(ASBMR)和罕见骨病联盟(RBDA)已经 成功向患者、医疗保健专业人员传播有关罕见骨病和OI的信息， 以及行业合作伙伴，从而扩大了该联盟的教育和培训任务的影响。 BBDC职业提升核心(CEC)计划在之前培训的基础上进行扩展 通过招募和支持医学生、牙医培训、博士前研究员、 对罕见疾病感兴趣的博士后研究员、遗传咨询师和初级教员。帮助 促进罕见疾病研究的职业生涯，BBDC CEC将提供一系列职业提升 活动包括：1)为博士后研究员和初级教员争取受保护的研究时间 OIF的Michael Geisman奖学金，2)提供与罕见疾病研究相关的教学培训，3) 让受训者利用来自纵向研究的数据来补充机械数据 在实验室中产生，4)提供机会在内外展示他们的研究成果 财团，以及5)参与OIF的社区和教育推广计划。CEC 将利用其现场机构的大量培训资源，包括：1)NIH资助的知识分子和 发展障碍研究中心(IDDRC)、临床和翻译科学奖(CTSA)、 和培训补助金(例如，K12、K30和T32机制)，2)医学和研究生院项目，3) OIF的教育推广计划，以实现其目标。

PROJECT SUMMARY (Career Enhancement Core) A key goal of the Rare Disease Clinical Research Network (RDCRN) is to train the next-generation of rare disease clinical/translational investigators. The Brittle Bone Disorders Consortium (BBDC) has made significant progress towards contributing to this mission. Over the past five years, the BBDC provided Geisman research fellowship funding to seven highly-qualified early-stage investigators (out of a total of 14 funded by the OIF). Additionally, by leveraging Institutional resources, the BBDC investigators mentored another 10 young investigators in research projects directly related to OI. Furthermore, 20 trainees received travel awards to attend the annual scientific meetings of the OIF and the RDCRN's Conference on Clinical Research for Rare Diseases where they had opportunities to present their scientific work. BBDC enhancement activities also ensured that the trainees actively engage with the OIF, the primary patient advocacy group (PAG), and to interact with individuals and families affected by OI. The success of these strategies is best exemplified by the fact that trainees supported by the BBDC have published over 80 publications in the short span of time coinciding with years 1-5 of the BBDC. In addition to these career enhancing activities, the BBDC, in partnership with the OIF, and professional organizations like the American Society for Bone and Mineral Research (ASBMR), National Osteoporosis Foundation, and the Rare Bone Disease Alliance (RBDA), has successfully disseminated information about rare bone diseases and OI to patients, healthcare professionals, and industry partners, thus broadening the impact of the education and training mission of the consortium. The BBDC Career Enhancement Core (CEC) proposes to expand upon the previous training achievements by recruiting and supporting medical students, dentists in training, predoctoral fellows, postdoctoral fellows, genetic counselors, and junior faculty who are interested in rare diseases. To help facilitate a career in rare diseases research, the BBDC CEC will provide a range of career enhancement activities including: 1) procuring protected research time for postdoctoral fellows and junior faculty through the Michael Geisman Fellowship from the OIF, 2) providing didactic training relevant to rare diseases research, 3) engaging the trainees to utilize the data from the longitudinal study to complement the mechanistic data generated in the laboratory, 4) providing opportunities to showcase their research work both within and outside the consortium, and 5) partaking in the community and educational outreach programs of the OIF. The CEC will leverage numerous training resources at its site institutions including: 1) NIH funded Intellectual and Developmental Disabilities Research Centers (IDDRC), Clinical and Translational Science Awards (CTSA), and Training Grants (e.g., K12, K30, and T32 mechanisms), 2) medical and graduate school programs, and 3) educational outreach program of the OIF, to accomplish its goals.