Central Laboratory Core

中心实验室核心项目摘要/摘要 中央实验室核心是U54收集的样本的中央存储设施 预防艾滋病毒携带者HPV相关癌症伙伴关系：巴西、墨西哥和 波多黎各(PHAC-BMPR)项目，由安娜·R·朱利亚诺博士和路易莎·L·维拉共同领导。这个核心是建立在 人乳头瘤病毒感染男性(HIM)研究实验室的广泛基础设施和国际经验 核心自2004年开始运作，支持在美国、墨西哥和巴西进行的研究。最初是一个核心到 支持HPV自然病史研究2012年扩展核心基础设施，将HPV疫苗纳入临床 在墨西哥和南非试运行。此外，核心还建立在丰富的经验和 巴西的基础设施管理生物库和宫颈HPV检测，以支持路德维希-麦吉尔 自1994年开始研究人乳头瘤病毒自然史。CL Core的总体目标是接收、处理、存储和 发布高质量、注解良好的生物检疫制剂，以支持拟议的三项临床试验 拉丁美洲艾滋病毒携带者中的人乳头瘤病毒相关癌症。此外，CL Core将 为终点判定、DNA提取、 HPV基因分型和拟议临床试验的免疫学评估。核心活动将是 集中在两个实验室，一个由莫菲特癌症中心的朱利亚诺博士领导，另一个由比利亚博士领导 S大学，巴西。

CENTRAL LABORATORY CORE PROJECT SUMMARY/ABSTRACT The Central Laboratory Core serves as the central storage facility for specimens collected by the U54 Partnership for Prevention of HPV-Associated Cancers in People Living with HIV: Brazil, Mexico and Puerto Rico (PHAC-BMPR) Program, co-led by Drs. Anna R Giuliano and Luisa L Villa. This core builds on the extensive infrastructure and international experience of the HPV Infection in Men (HIM) Study laboratory core in operation since 2004 supporting research conducted in the US, Mexico, and Brazil. Originally a core to support HPV natural history research the core infrastructure expanded in 2012 to include HPV vaccine clinical trial operations in Mexico and South Africa. In addition, the core builds on the extensive experience and infrastructure in Brazil managing the biorepository and cervical HPV testing in support of the Ludwig-McGill HPV Natural History Study since 1994. The overall goal of the CL Core is to receive, process, store, and release high-quality, well-annotated biospecimens in support of the three clinical trials proposed to reduce HPV-related cancers among men and women living with HIV in Latin America. In addition, the CL Core will provide centralized research-quality cervical pathology evaluation for endpoint adjudication, DNA extraction, HPV genotyping, and immunological evaluation for the proposed clinical trials. Core activities will be centralized in two laboratories, one led by Dr. Giuliano at the Moffitt Cancer Center and one led by Dr. Villa at the University of São Paulo, Brazil.